Publication Name	World Journal of Gastroenterology
Manuscript ID	99629
Country	Taiwan

Received	2024-07-27 02:37
Peer-Review Started	2024-07-27 02:37
To Make the First Decision
Return for Revision	2024-09-04 02:16
Revised	2024-09-17 16:58
Second Decision	2024-10-22 03:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-22 05:38
Articles in Press	2024-10-22 05:38
Publication Fee Transferred	2024-10-24 03:20
Edit the Manuscript by Language Editor	2024-11-13 03:29
Typeset the Manuscript	2024-11-19 07:44
Publish the Manuscript Online	2024-11-29 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Yen-Yang Chen, Chen-Chi Wang, Chun-Yi Chuang, Yung-An Tsou, Yen-Chun Peng, Chi-Sen Chang and Han-Chung Lien
Funding Agency and Grant Number
Corresponding Author	Han-Chung Lien, MD, PhD, Associate Professor, Division of Gastroenterology, Center for Functional Esophageal Disorders, Taichung Veterans General Hospital, No. 1650 Taiwan Boulevard, Section 4, Taichung 435, Taiwan. lhc@vghtc.gov.tw
Key Words	Pharyngeal acid reflux episodes; Laryngopharyngeal reflux; Hypopharyngeal multichannel intraluminal impedance-potential of hydrogen; 3- potential of hydrogen-sensor; Proton pump inhibitors
Core Tip	This study examines the link between pharyngeal acid reflux (PAR) episodes and the effectiveness of proton pump inhibitor (PPI) therapy in laryngopharyngeal reflux (LPR) patients. Using specific potential of hydrogen criteria for PAR episodes detected by hypopharyngeal multichannel intraluminal impedance-potential of hydrogen, researchers found that patients with ≥ 2 baseline PAR episodes had a significantly higher response rate (73%) to PPI therapy compared to those without acidic reflux (33%). These findings underscore the importance of hypopharyngeal reflux monitoring, as PAR episodes appear to be crucial in predicting PPI efficacy. Hence, the authors recommend a personalized approach to LPR diagnosis and treatment in order to enhance patient outcomes.
Publish Date	2024-11-29 08:40
Citation	<p>Chen YY, Wang CC, Chuang CY, Tsou YA, Peng YC, Chang CS, Lien HC. Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy. <i>World J Gastroenterol</i> 2024; 30(48): 5162-5173</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i48/5162.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i48.5162

Full Article (PDF)	WJG-30-5162-with-cover.pdf
STROBE Statement	99629-STROBE-statement.pdf
Manuscript File	99629_Auto_Edited_013020.docx
Answering Reviewers	99629-answering-reviewers.pdf
Audio Core Tip	99629-audio.m4a
Biostatistics Review Certificate	99629-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99629-conflict-of-interest-statement.pdf
Copyright License Agreement	99629-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99629-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	99629-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	99629-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99629-non-native-speakers.pdf
Supplementary Material	99629-supplementary-material.pdf
Peer-review Report	99629-peer-reviews.pdf
Scientific Misconduct Check	99629-scientific-misconduct-check.png
Scientific Editor Work List	99629-scientific-editor-work-list.pdf
CrossCheck Report	99629-crosscheck-report.png
CrossCheck Report	99629-crosscheck-report.pdf