Publication Name	World Journal of Gastroenterology
Manuscript ID	99750
Country	China

Received	2024-08-21 06:06
Peer-Review Started	2024-07-29 11:58
To Make the First Decision
Return for Revision	2024-10-23 01:37
Revised	2024-11-05 17:20
Second Decision	2024-12-10 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-10 03:04
Articles in Press	2024-12-10 03:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-02 02:31
Publish the Manuscript Online	2025-01-10 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Reevaluating Calculus bovis: Modulating the liver cancer immune microenvironment via the Wnt/β-catenin pathway
Manuscript Source	Invited Manuscript
All Author List	Shi-Yue Wang and Kai-Juan Wang
Funding Agency and Grant Number
Corresponding Author	Kai-Juan Wang, Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, Henan Province, China. kjwang@163.com
Key Words	Liver cancer; Calculus bovis; Wnt/β-catenin signalling pathway; Tumour-associated macrophages; Tumour immune microenvironment; Anti-tumour therapy; Traditional Chinese medicine
Core Tip	This study highlights the role of Calculus bovis (CB) in regulating the liver cancer immune microenvironment through the Wnt/β-catenin signalling pathway. Active components in CB inhibit Wnt/β-catenin activation, reduce M2 tumour-associated macrophage polarization, and enhance anti-tumour immunity, suppressing liver cancer growth and spread. Multilevel experiments confirm CB’s potential as an anti-tumour agent, offering a foundation for new liver cancer treatments based on traditional Chinese medicine. Future research should explore CB’s effects across liver cancer subtypes and in combination with modern therapies to improve treatment efficacy and safety.
Publish Date	2025-01-10 08:40
Citation	<p>Wang SY, Wang KJ. Reevaluating Calculus bovis: Modulating the liver cancer immune microenvironment via the Wnt/β-catenin pathway. <i>World J Gastroenterol</i> 2025; 31(6): 99750</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i6/99750.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i6.99750

Full Article (PDF)	WJG-31-99750-with-cover.pdf
Manuscript File	99750_Auto_Edited_082150.docx
Answering Reviewers	99750-answering-reviewers.pdf
Audio Core Tip	99750-audio.mp3
Conflict-of-Interest Disclosure Form	99750-conflict-of-interest-statement.pdf
Copyright License Agreement	99750-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99750-non-native-speakers.pdf
Peer-review Report	99750-peer-reviews.pdf
Scientific Misconduct Check	99750-scientific-misconduct-check.png
Scientific Editor Work List	99750-scientific-editor-work-list.pdf
CrossCheck Report	99750-crosscheck-report.pdf