Publication Name	World Journal of Gastroenterology
Manuscript ID	99808
Country	Canada

Received	2024-07-30 21:51
Peer-Review Started	2024-07-30 21:51
To Make the First Decision
Return for Revision	2024-10-11 04:14
Revised	2024-10-16 18:07
Second Decision	2024-11-07 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-07 06:25
Articles in Press	2024-11-07 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-15 07:06
Publish the Manuscript Online	2024-11-26 07:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Exploring non-invasive diagnostics and non-imaging approaches for pediatric metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Toshifumi Yodoshi
Funding Agency and Grant Number
Corresponding Author	Toshifumi Yodoshi, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada. toshifumi.yodoshi@sickkids.ca
Key Words	Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Insulin resistance; Oxidative stress
Core Tip	This article reviews non-invasive diagnostic approaches and liver fibrosis assessment methods for pediatric metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting the recent nomenclature change and the significance of early diagnosis. MASLD is the most common chronic liver disease in children, with approximately half of the pediatric cases progressing to metabolic dysfunction-associated steatohepatitis at diagnosis and already having comorbidities such as renal disease, sarcopenia, hypertension, and type 2 diabetes mellitus. While liver biopsy is the gold standard for diagnosing MASLD, it is invasive. To avoid liver biopsy in children, developing non-invasive methods such as biomarkers, serum tests, and imaging is essential.
Publish Date	2024-11-26 07:20
Citation	<p>Yodoshi T. Exploring non-invasive diagnostics and non-imaging approaches for pediatric metabolic dysfunction-associated steatotic liver disease. <i>World J Gastroenterol</i> 2024; 30(47): 5070-5075</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i47/5070.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i47.5070

Full Article (PDF)	WJG-30-5070-with-cover.pdf
Manuscript File	99808_Auto_Edited_062701.docx
Answering Reviewers	99808-answering-reviewers.pdf
Audio Core Tip	99808-audio.mp3
Conflict-of-Interest Disclosure Form	99808-conflict-of-interest-statement.pdf
Copyright License Agreement	99808-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99808-non-native-speakers.pdf
Peer-review Report	99808-peer-reviews.pdf
Scientific Misconduct Check	99808-scientific-misconduct-check.png
Scientific Editor Work List	99808-scientific-editor-work-list.pdf
CrossCheck Report	99808-crosscheck-report.pdf