Publication Name	World Journal of Gastroenterology
Manuscript ID	99885
Country	United Kingdom

Received	2024-08-01 17:18
Peer-Review Started	2024-08-01 17:18
To Make the First Decision
Return for Revision	2024-09-07 15:04
Revised	2024-09-10 06:38
Second Decision	2024-09-14 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-14 06:23
Articles in Press	2024-09-14 06:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-19 10:03
Publish the Manuscript Online	2024-09-29 09:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Editorial
Article Title	Is Helicobacter pylori infection protective against esophageal cancer?
Manuscript Source	Invited Manuscript
All Author List	Rick Maity, Arkadeep Dhali and Jyotirmoy Biswas
Funding Agency and Grant Number
Corresponding Author	Arkadeep Dhali, MBBS, Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom. arkadipdhali@gmail.com
Key Words	Helicobacter pylori; Helicobacter pylori infection; Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Barrett’s esophagus; Microbiota; Dysbiosis; Eradication
Core Tip	Helicobacter pylori (H. pylori) infection, while being a risk factor for gastric cancer, may afford protection against esophageal cancer (EC). The two major subtypes of EC, i.e., esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), have different etiologies and risk factors. Recent studies have unequivocally established the inverse association between H. pylori infection and EAC, however there was no significant association with ESCC. H. pylori infection may protect against EAC by inducing atrophic gastritis, altering serum ghrelin levels, and triggering cancer cell apoptosis. Contrary to prevailing concerns, H. pylori eradication does not increase the risk of EC.
Publish Date	2024-09-29 09:24
Citation	<p>Maity R, Dhali A, Biswas J. Is Helicobacter pylori infection protective against esophageal cancer? <i>World J Gastroenterol</i> 2024; 30(38): 4168-4174</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i38/4168.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i38.4168

Full Article (PDF)	WJG-30-4168-with-cover.pdf
Manuscript File	99885_Auto_Edited_005434.docx
Answering Reviewers	99885-answering-reviewers.pdf
Audio Core Tip	99885-audio.mp3
Conflict-of-Interest Disclosure Form	99885-conflict-of-interest-statement.pdf
Copyright License Agreement	99885-copyright-assignment.pdf
Peer-review Report	99885-peer-reviews.pdf
Scientific Misconduct Check	99885-scientific-misconduct-check.png
Scientific Editor Work List	99885-scientific-editor-work-list.pdf
CrossCheck Report	99885-crosscheck-report.pdf
CrossCheck Report	99885-crosscheck-report.png