Publication Name	World Journal of Diabetes
Manuscript ID	99936
Country	Bulgaria

Received	2024-08-09 03:16
Peer-Review Started	2024-08-11 14:55
To Make the First Decision
Return for Revision	2024-11-22 11:29
Revised	2024-12-06 10:31
Second Decision	2025-01-09 02:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-07 02:57
Articles in Press	2025-02-07 02:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-02-14 23:10
Typeset the Manuscript	2025-02-20 08:16
Publish the Manuscript Online	2025-02-28 10:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Minireviews
Article Title	T helper 17 cells and interleukin-17 immunity in type 1 diabetes: From pathophysiology to targeted immunotherapies
Manuscript Source	Invited Manuscript
All Author List	Georgi Vasilev, Maria Kokudeva, Elina Siliogka, Nathalia Padilla, Russka Shumnalieva, David Della-Morte, Camillo Ricordi, Antoaneta Mihova, Marco Infante and Tsvetelina Velikova
Funding Agency and Grant Number	Funding Agency Grant Number European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria BG-RRP-2.004-0008
Corresponding Author	Georgi Vasilev, Assistant Professor, MD, PhD, Department of Clinic of Neurology and Emergency Medicine, UMHAT "Sv Georgi", Blvd Peshtersko Shose 66, Plovdiv 4000, Bulgaria. vvasilev.georgi@gmail.com
Key Words	Type 1 diabetes; T helper 17 cells; Interleukin-17; T helper 1 cells; Regulatory T cells; Anti-interleukin-17 treatment; Th17-targeted treatment
Core Tip	Recent research has identified Th17 cells and their primary effector cytokine, interleukin (IL)-17, as key players in the pathophysiology of type 1 diabetes (T1D). Th17 cells contribute to the autoimmune responses directed against pancreatic beta cells in T1D, promoting insulitis and beta-cell destruction. Understanding the role of Th17 cells and IL-17 in T1D pathophysiology offers new opportunities for targeted immunotherapies, which aim to modulate the altered immune responses and preserve residual beta-cell function in presymptomatic and new-onset T1D. Therefore, Th17 cell- and IL-17-targeted interventions may potentially represent future disease-modifying therapies able to improve clinical outcomes in patients with T1D at different stages of the disease.
Publish Date	2025-02-28 10:47
Citation	<p>Vasilev G, Kokudeva M, Siliogka E, Padilla N, Shumnalieva R, Della-Morte D, Ricordi C, Mihova A, Infante M, Velikova T. T helper 17 cells and interleukin-17 immunity in type 1 diabetes: From pathophysiology to targeted immunotherapies. <i>World J Diabetes</i> 2025; 16(4): 99936</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i4/99936.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i4.99936

Full Article (PDF)	WJD-16-99936-with-cover.pdf
Manuscript File	99936_Auto_Edited_013350.docx
Answering Reviewers	99936-answering-reviewers.pdf
Audio Core Tip	99936-audio.mp3
Conflict-of-Interest Disclosure Form	99936-conflict-of-interest-statement.pdf
Copyright License Agreement	99936-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99936-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	99936-non-native-speakers.pdf
Peer-review Report	99936-peer-reviews.pdf
Journal Editor-in-Chief Review Report	99936-journal-editor-in-chief.pdf
Scientific Misconduct Check	99936-scientific-misconduct-check.png
Scientific Editor Work List	99936-scientific-editor-work-list.pdf
CrossCheck Report	99936-crosscheck-report.pdf