Publication Name	World Journal of Gastroenterology
Manuscript ID	100004
Country	India

Received	2024-08-05 07:04
Peer-Review Started	2024-08-05 07:04
To Make the First Decision
Return for Revision	2024-09-07 14:57
Revised	2024-09-12 09:09
Second Decision	2024-09-25 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-25 06:13
Articles in Press	2024-09-25 06:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-02 11:16
Typeset the Manuscript	2024-10-10 06:04
Publish the Manuscript Online	2024-10-23 04:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Harnessing the power of Calculus bovis: Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Himanshi Goyal, Sachin Parwani, Kaneez Fatima and Jyotdeep Kaur
ORCID	Author(s) ORCID Number Himanshi Goyal http://orcid.org/0009-0004-4769-9610 Jyotdeep Kaur http://orcid.org/0000-0003-0284-4517
Funding Agency and Grant Number
Corresponding Author	Jyotdeep Kaur, PhD, Professor, Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. jyotdeep2001@yahoo.co.in
Key Words	Calculus bovis; Liver cancer; Tumor-associated macrophages; M2 polarisation; Wnt signalling pathway
Core Tip	Chinese traditional medicine-calculus bovis (CB) is known to affect tumor biology by showing promise in inhibiting hepatocellular carcinoma (HCC) progression by targeting the Wnt signaling pathway. The study highlights CB's anti-cancer properties, particularly against liver cancer, through modulation of pathways such as phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin, and compounds like oleanolic acid and ursolic acid. Additionally, CB sativus has shown efficacy in reducing hepatic inflammation and oxidative stress, suggesting potential therapeutic strategies for HCC, warranting further clinical validation.
Publish Date	2024-10-23 04:32
Citation	<p>Goyal H, Parwani S, Fatima K, Kaur J. Harnessing the power of Calculus bovis: Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma. <i>World J Gastroenterol</i> 2024; 39(41): 4496-4502</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i41/4496.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i41.4496

Full Article (PDF)	WJG-30-4496-with-cover.pdf
Manuscript File	100004_Auto_Edited_030930.docx
Answering Reviewers	100004-answering-reviewers.pdf
Audio Core Tip	100004-audio.m4a
Conflict-of-Interest Disclosure Form	100004-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	100004-non-native-speakers.pdf
Peer-review Report	100004-peer-reviews.pdf
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Scientific Editor Work List	100004-scientific-editor-work-list.pdf
CrossCheck Report	100004-crosscheck-report.pdf