| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yolanda Real Martinez, Carlos Ernesto Fernandez-Garcia, Esther Fuertes-Yebra, Mario Calvo Soto, Angela Berlana, Vicente Barrios, Maria Caldas, Leticia Gonzalez Moreno, Luisa Garcia-Buey, Begoña Molina Baena, Miguel Sampedro-Nuñez, Maria J Beceiro, C García-Monzón and Águeda González-Rodríguez |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yolanda Real Martinez, PhD, Department of Gastroenterology, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa, Universidad Autónoma de Madrid, Diego de Leon 62, Madrid 28006, Spain. yrealm@gmail.com |
| Key Words |
Skeletal muscle alterations; Myokines; Metabolic dysfunction-associated steatotic liver disease; Liver fibrosis; Hepatosteatosis |
| Core Tip |
Skeletal muscle alterations (SMA), with sarcopenia being its maximum expression, share pathophysiology mechanisms with metabolic dysfunction-associated steatotic liver disease (MASLD), in which inflammation, insulin resistance and physical inactivity are key factors. Previous studies, mainly in Asian population, describe these alterations, especially reduced muscle function, in patients with a higher degree of liver fibrosis and steatosis. We aimed to determine the prevalence of SMA in patients diagnosed with MASLD in an outpatient setting in Spain, and to analyze myokines as potential biomarkers of inflammation. We did not find significant SMA, but we found a marked increase in serum levels of irisin and fibroblast growth factor 21 in advanced disease stages, which deserves further assessment. |
| Publish Date |
2025-01-20 07:38 |
| Citation |
Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039
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| URL |
https://www.wjgnet.com/1007-9327/full/v31/i7/100039.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i7.100039 |
