Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	100126
Country	India

Received	2024-08-07 14:16
Peer-Review Started	2024-08-07 14:16
To Make the First Decision
Return for Revision	2024-12-12 08:38
Revised	2024-12-21 09:37
Second Decision	2025-01-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 07:18
Articles in Press	2025-01-02 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-01-07 05:11
Typeset the Manuscript	2025-01-22 01:21
Publish the Manuscript Online	2025-02-24 09:25

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Anesthesiology
Manuscript Type	Editorial
Article Title	Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients
Manuscript Source	Invited Manuscript
All Author List	Chandra K Pandey and Abhishek Kumar
ORCID	Author(s) ORCID Number Chandra K Pandey http://orcid.org/0000-0003-4472-0547 Abhishek Kumar http://orcid.org/0000-0001-7225-8068
Funding Agency and Grant Number
Corresponding Author	Chandra K Pandey, MD, Professor, Department of Anaesthesiology, Medanta Hospital Lucknow, Sultanpur Road, Lucknow 226030, Uttar Pradesh, India. ceekeypandey@gmail.com
Key Words	Colon cancer; Dexmedetomidine; General anaesthesia; Elderly; Radical colon cancer surgery; Cognitive function
Core Tip	Dexmedetomidine (Dex) is a significant drug that improves surgical outcomes in varied surgeries. The neuroprotective, opioid-sparing and sympatholytic properties of Dex have shown improved outcomes in the elderly population in various surgeries including radical colon surgeries. The decline in the incidence and severity of postoperative cognitive dysfunction, the decreased surge in proinflammatory markers, improved regional cerebral oxygenation and better pain control due to Dex lead to improved outcomes, early discharge and decreased healthcare costs in this vulnerable group of patients.
Publish Date	2025-02-24 09:25
Citation	<p>Pandey CK, Kumar A. Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients. <i>World J Gastrointest Surg</i> 2025; 17(3): 100126</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i3/100126.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i3.100126

Full Article (PDF)	WJGS-17-100126-with-cover.pdf
Manuscript File	100126_Auto_Edited_004157.docx
Answering Reviewers	100126-answering-reviewers.pdf
Audio Core Tip	100126-audio.mp3
Conflict-of-Interest Disclosure Form	100126-conflict-of-interest-statement.pdf
Copyright License Agreement	100126-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100126-non-native-speakers.pdf
Peer-review Report	100126-peer-reviews.pdf
Scientific Misconduct Check	100126-scientific-misconduct-check.png
Scientific Editor Work List	100126-scientific-editor-work-list.pdf
CrossCheck Report	100126-crosscheck-report.pdf