Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100152
Country	China

Received	2024-08-11 14:45
Peer-Review Started	2024-08-11 14:45
To Make the First Decision
Return for Revision	2024-10-20 11:03
Revised	2024-11-03 05:48
Second Decision	2024-12-13 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-13 06:25
Articles in Press	2024-12-13 06:25
Publication Fee Transferred	2024-11-09 01:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-22 03:43
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Penile metastasis from colon cancer with BRAFV600E mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Chen Wu, Hua-Xi Cheng, Qiu-Sheng Lan, He-Yang Xu, Yu-Jie Zeng, Wei Lai and Zhong-Hua Chu
ORCID	Author(s) ORCID Number Jun-Chen Wu http://orcid.org/0009-0001-9154-5721 Hua-Xi Cheng http://orcid.org/0009-0005-2599-6267 Qiu-Sheng Lan http://orcid.org/0009-0001-7999-1446 He-Yang Xu http://orcid.org/0009-0003-8440-1230 Yu-Jie Zeng http://orcid.org/0009-0009-4705-216X Wei Lai http://orcid.org/0009-0008-3536-3895 Zhong-Hua Chu http://orcid.org/0009-0007-5721-5845
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81871981 Natural Science Foundation of Guangdong Province 2022A1515012348 and 2023A1515010457
Corresponding Author	Zhong-Hua Chu, MD, PhD, Professor, Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yan Jiang West Road, Guangzhou 510120, Guangdong Province, China. chuzhh@mail.sysu.edu.cn
Key Words	Colon cancer; Penile metastasis; BRAFV600E mutation; Targeted therapy; Case report
Core Tip	Despite the increasing incidence and prevalence of colorectal cancer among malignant tumors, penile metastasis originating from colorectal cancer remains a rare occurrence. The precise mechanism underlying penile metastasis of colorectal cancer remains elusive, and its specific treatment remains a subject of controversy, particularly in patients with BRAFV600E mutation, which often signifies an unfavorable prognosis. In our case, the treatment of BRAF/MEK-targeted therapy (dabrafenib and trametinib) plus cetuximab demonstrated promising outcomes, leading to tumor regression and prolonged survival, thereby offering valuable insights for the management of analogous cases.
Publish Date	2025-02-14 10:33
Citation	<p>Wu JC, Cheng HX, Lan QS, Xu HY, Zeng YJ, Lai W, Chu ZH. Penile metastasis from colon cancer with BRAFV600E mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report. <i>World J Gastrointest Oncol</i> 2025; 17(3): 100152</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/100152.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.100152

Full Article (PDF)	WJGO-17-100152-with-cover.pdf
CARE Checklist–2016	100152-CARE-Checklist-2016.pdf
Manuscript File	100152_Auto_Edited_064244.docx
Answering Reviewers	100152-answering-reviewers.pdf
Audio Core Tip	100152-audio.m4a
Conflict-of-Interest Disclosure Form	100152-conflict-of-interest-statement.pdf
Copyright License Agreement	100152-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100152-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	100152-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	100152-non-native-speakers.pdf
Peer-review Report	100152-peer-reviews.pdf
Scientific Misconduct Check	100152-scientific-misconduct-check.png
Scientific Editor Work List	100152-scientific-editor-work-list.pdf
CrossCheck Report	100152-crosscheck-report.pdf