Publication Name	World Journal of Experimental Medicine
Manuscript ID	100166
Country	Germany

Received	2024-08-16 08:28
Peer-Review Started	2024-08-08 14:39
To Make the First Decision
Return for Revision	2024-12-17 03:47
Revised	2025-01-04 17:21
Second Decision	2025-01-15 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-15 11:09
Articles in Press	2025-01-15 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-06 09:25
Publish the Manuscript Online	2025-04-16 05:36

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling
Manuscript Source	Invited Manuscript
All Author List	Marc Irqsusi, Fiona R Rodepeter, Madeline Günther, Andreas Kirschbaum and Sebastian Vogt
ORCID	Author(s) ORCID Number Sebastian Vogt http://orcid.org/0000-0002-4485-2083
Funding Agency and Grant Number
Corresponding Author	Sebastian Vogt, Associate Professor, MD, Senior Researcher, Department of Heart Surgery, Philipps-University Marburg, Baldinger Street 1, Marburg 35043, Hesse, Germany. vogts@med.uni-marburg.de
Key Words	Matrix metalloproteinases; Tissue inhibitor of metalloproteinases; Acute aortic dissection; Aortic aneurysm; Extracellular matrix remodeling; Pathogenesis
Core Tip	Immunohistological examinations of the aortic wall reveal a different distribution of matrix metalloproteinases (MMPs) and their inhibitors in the aortic wall of aneurysms and dissections. While degenerative changes tend to play a role in aneurysmal changes, dissections are caused by impaired tissue nutrition and oxygenation due to dysfunctional capillarization. The tissue layers of the aorta are subject to specific stresses that lead to different expressions of MMPs and tissue inhibitor of metalloproteinases.
Publish Date	2025-04-16 05:36
Citation	<p>Irqsusi M, Rodepeter FR, Günther M, Kirschbaum A, Vogt S. Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling. <i>World J Exp Med</i> 2025; 15(2): 100166</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i2/100166.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i2.100166

Full Article (PDF)	WJEM-15-100166-with-cover.pdf
Manuscript File	100166_Auto_Edited_035128.docx
Answering Reviewers	100166-answering-reviewers.pdf
Audio Core Tip	100166-audio.m4a
Conflict-of-Interest Disclosure Form	100166-conflict-of-interest-statement.pdf
Copyright License Agreement	100166-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100166-non-native-speakers.pdf
Peer-review Report	100166-peer-reviews.pdf
Scientific Misconduct Check	100166-scientific-misconduct-check.png
Scientific Editor Work List	100166-scientific-editor-work-list.pdf
CrossCheck Report	100166-crosscheck-report.pdf