| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Recurrence and influencing factors of hepatitis B surface antigen seroclearance induced by peginterferon alpha-based regimens
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Lu, Meng Zhang, Zi-Han Liu, Miao Hao, Yan Tian, Mei Li, Feng-Ping Wu, Wen-Jun Wang, Juan-Juan Shi, Xin Zhang, Xiao-Li Jia, Zi-Cheng Jiang, Xue-Mei Li, Guang-Hua Xu, Ya-Ping Li and Shuang-Suo Dang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2023YFC2308105 |
|
| Corresponding Author |
Shuang-Suo Dang, PhD, Professor, Department of Infectious Diseases, The Second Affiliated Hospital of Xi’an Jiaotong University, No.157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. dang212@126.com |
| Key Words |
Chronic hepatitis B; Peginterferon alpha; Hepatitis B surface antigen seroclearance; Hepatitis B surface antigen recurrence; Clinical cure |
| Core Tip |
Hepatitis B surface antigen seroclearance is an ideal target for peginterferon alpha (peg-IFN-α) treatment in patients with chronic hepatitis B and a focus of global research. However, there is limited information about the duration of seroclearance after peg-IFN-α withdrawal. This study examined follow-up observational data after peg-IFN-α withdrawal among patients who achieved functional cure at three centers. The longest follow-up duration was 252 weeks, representing one of the longest follow-up times currently available. We believe that this study offers valuable guidance and reference for the clinical use of peg-IFN-α, including the optimal timing of treatment cessation and the importance of continuous and standardized follow-up after treatment. |
| Publish Date |
2024-11-12 06:08 |
| Citation |
<p>Lu R, Zhang M, Liu ZH, Hao M, Tian Y, Li M, Wu FP, Wang WJ, Shi JJ, Zhang X, Jia XL, Jiang ZC, Li XM, Xu GH, Li YP, Dang SS. Recurrence and influencing factors of hepatitis B surface antigen seroclearance induced by peginterferon alpha-based regimens. <i>World J Gastroenterol</i> 2024; 30(44): 4725-4737</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i44/4725.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i44.4725 |
