| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Platelet activation relieves liver portal hypertension via lymphatic system though classical vascular endothelial growth factor receptor-3 signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Chen, Jin-Bo Zhao, Guang-Bo Wu, Zheng-Hao Wu, Gu-Qing Luo, Zhi-Feng Zhao, Chi-Hao Zhang, Jia-Yun Lin, Hong-Jie Li, Xiao-Liang Qi, Hai-Zhong Huo, Abudukadier Tuersun, Qiang Fan, Lei Zheng and Meng Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82100639 |
| National Natural Science Foundation of China |
No. 82200630 |
| National Natural Science Foundation of China |
No. 81970526 |
| Postdoctoral Scientific Research Foundation of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine |
No. 202401023 |
| Clinical Research Program of Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine |
No. JYLJ202124 |
| Shanghai Municipal Commission of Health and Family Planning |
No. 20244Y0195 |
| Shanghai Municipal Commission of Health and Family Planning |
No. 20234Y0132 |
| Fundamental Research Program Funding of Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
No. JYZZ162 |
| Science Foundation of Xinjiang Uygur Natural Autonomous Region |
No. 2022D01F17 |
|
| Corresponding Author |
Meng Luo, PhD, Department of General Surgery, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, No. 639 Manufacturing Bureau Road, Shanghai 200011, China. luosh9hospital@sina.com |
| Key Words |
Portal hypertension; Cirrhosis; Lymphangiogenesis; Platelets; Vascular endothelial growth factor C |
| Core Tip |
In the sequencing of the classic bile duct ligation model of portal hypertension in rats, platelet activation plays a crucial role in lymphagiogenesis. Effective lymphatic drainage may alleviate the high flow fluid environment of the hepatic portal vein caused by various etiologies. Based on this research, Platelet-rich plasma enhanced intrahepatic and extrahepatic proliferation of lymphatics and simultaneously alleviated portal hypertension. |
| Publish Date |
2025-02-26 04:21 |
| Citation |
<p>Chen M, Zhao JB, Wu GB, Wu ZH, Luo GQ, Zhao ZF, Zhang CH, Lin JY, Li HJ, Qi XL, Huo HZ, Tuersun A, Fan Q, Zheng L, Luo M. Platelet activation relieves liver portal hypertension via lymphatic system though classical vascular endothelial growth factor receptor-3 signaling pathway. <i>World J Gastroenterol</i> 2025; 31(10): 100194</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i10/100194.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i10.100194 |
