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Articles Published Processes
10/23/2024 4:32:17 AM | Browse: 132 | Download: 514
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Received |
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2024-08-09 22:58 |
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Peer-Review Started |
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2024-08-09 22:58 |
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First Decision by Editorial Office Director |
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2024-09-20 01:33 |
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Return for Revision |
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2024-09-20 01:33 |
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Revised |
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2024-09-27 00:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-10-08 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-08 06:21 |
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Articles in Press |
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2024-10-08 06:21 |
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Edit the Manuscript by Language Editor |
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2024-10-14 22:42 |
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Typeset the Manuscript |
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2024-10-15 07:03 |
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Publish the Manuscript Online |
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2024-10-23 04:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
MicroRNA-206 as promising epigenetic approach to modulate tumor-associated macrophages in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Davide Ramoni and Fabrizio Montecucco |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fabrizio Montecucco, MD, PhD, Full Professor, First Clinic of Internal Medicine, Department of Internal Medicine, IRCCS Ospedale Policlinico San Martino, 6 Viale Benedetto XV, Genoa 16132, Italy. fabrizio.montecucco@unige.it |
| Key Words |
Epigenetic regulation; Hepatocellular carcinoma; Non-coding RNAs; MicroRNA-206; Tumor-associated macrophages; Tumor microenvironment |
| Core Tip |
Hepatocellular carcinoma is a highly aggressive tumor often associated with chronic liver disease and cirrhosis, with limited treatment options for patients ineligible for surgery or transplantation. As a result, there is an urgent need to explore alternative therapeutic options. This letter highlights the modulation of M2-tumor-associated macrophages polarization via Wnt/β-catenin and other pathways, as well as the role of microRNAs (miR)-206 in promoting anti-tumor immunity. miR-206 stimulates M1 Kupffer cell polarization, recruits cluster of differentiation 8 + T cells, and inhibits the expansion of liver cancer stem cells. Understanding these mechanisms could pave the way for targeted therapies that improve outcomes for hepatocellular carcinoma patients. |
| Publish Date |
2024-10-23 04:32 |
| Citation |
Ramoni D, Montecucco F. MicroRNA-206 as promising epigenetic approach to modulate tumor-associated macrophages in hepatocellular carcinoma. World J Gastroenterol 2024; 30(41): 4503-4508 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i41/4503.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i41.4503 |
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