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Articles Published Processes
2/18/2025 9:00:56 AM | Browse: 57 | Download: 66
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Received |
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2024-08-10 06:18 |
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Peer-Review Started |
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2024-08-10 06:19 |
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To Make the First Decision |
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Return for Revision |
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2024-12-29 02:55 |
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Revised |
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2025-01-06 08:58 |
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Second Decision |
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2025-01-21 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-21 03:01 |
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Articles in Press |
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2025-01-21 03:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-06 02:06 |
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Publish the Manuscript Online |
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2025-02-18 09:00 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Perianal fistulizing Crohn’s disease: Mechanisms and treatment options focusing on cellular therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Payal Bhatnagar, Sherreen Elhariri, Ismail A S Burud and Nabil Eid |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nabil Eid, Assistant Professor, MD, PhD, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, No. 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my |
| Key Words |
Stem cell therapy; Crohn’s disease; Perianal fistulas; Regenerative medicine; Treatment outcomes; Extracellular vehicles; Autophagy; Magnetic resonance imaging |
| Core Tip |
Perianal fistulizing Crohn’s disease (PFCD) is a common complication of CD, characterized by complex pathogenic mechanisms involving inflammatory cell accumulation, particularly macrophages, and enhanced cytokine production. These processes drive epithelial-to-mesenchymal transition, myofibroblast activation, upregulation of matrix metalloproteinases, ultimately leading to fistula formation. While various medical and surgical options target inflammatory processes in this disease, recurrence remains a substantial challenge. Local administration of mesenchymal stem cells or their derived extracellular vehicles has emerged as a promising therapeutic strategy through suppression of the inflammatory cells and promotion of fistula healing in PFCD. Here we summarize the various mechanisms involved in PFCD pathogenesis, with particular emphasis on mesenchymal stem cell therapy and their derived extracellular vehicles. |
| Publish Date |
2025-02-18 09:00 |
| Citation |
<p>Bhatnagar P, Elhariri S, Burud IAS, Eid N. Perianal fistulizing Crohn’s disease: Mechanisms and treatment options focusing on cellular therapy. <i>World J Gastroenterol</i> 2025; 31(9): 100221</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i9/100221.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i9.100221 |
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