Publication Name	World Journal of Gastroenterology
Manuscript ID	100227
Country	China

Received	2024-08-10 10:45
Peer-Review Started	2024-08-10 10:45
To Make the First Decision
Return for Revision	2024-11-10 03:08
Revised	2024-11-22 15:51
Second Decision	2025-01-08 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-08 06:45
Articles in Press	2025-01-08 06:45
Publication Fee Transferred	2024-11-26 04:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-17 01:08
Publish the Manuscript Online	2025-01-23 05:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Behavioral Sciences
Manuscript Type	Basic Study
Article Title	Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Jing Wang, Yi-Hong Fan, Wan-Ting Cao, Rong Huang, Xin-Yi Yao and Meng-Lin Li
ORCID	Author(s) ORCID Number Jing-Jing Wang http://orcid.org/0000-0002-1702-7942 Yi-Hong Fan http://orcid.org/0000-0001-8217-9793 Rong Huang http://orcid.org/0000-0002-8360-7777 Meng-Lin Li http://orcid.org/0009-0008-6801-8705
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Administration of Traditional Chinese Medicine 2021ZA057
Corresponding Author	Yi-Hong Fan, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yhfansjr@163.com
Key Words	Wuling powder; Ulcerative colitis; Depression; Brain-derived neurotrophic factor; Brain-derived neurotrophic factor precursor
Core Tip	A common psychological problem in patients with ulcerative colitis is varying degrees of depression, which can cause the patient’s condition to worsen. Wuling powder is widely used to treat anxiety, depression, insomnia and headache. Previous studies have found that the balance between brain-derived neurotrophic factor (BDNF) precursor/p75 neurotrophin receptor/sortilin and BDNF/tropomyosin receptor kinase B signalling is essential for maintaining brain homeostasis and preventing the development of depressive behaviours. Our study suggests that Wuling powder may play an antidepressant role by regulating the balance of the BDNF precursor/p75 neurotrophin receptor/sortilin and BDNF/tropomyosin receptor kinase B signalling pathways. Moreover, Wuling powder combined with mesalazine can further relieve intestinal inflammation in mice with ulcerative colitis and depression.
Publish Date	2025-01-23 05:47
Citation	<p>Wang JJ, Fan YH, Cao WT, Huang R, Yao XY, Li ML. Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression. <i>World J Gastroenterol</i> 2025; 31(8): 100227</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i8/100227.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i8.100227

Full Article (PDF)	WJG-31-100227-with-cover.pdf
The ARRIVE Guidelines	100227-The-ARRIVE-Guidelines.pdf
Manuscript File	100227_Auto_Edited_002658.docx
Answering Reviewers	100227-answering-reviewers.pdf
Audio Core Tip	100227-audio.mp3
Biostatistics Review Certificate	100227-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100227-conflict-of-interest-statement.pdf
Copyright License Agreement	100227-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100227-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	100227-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	100227-non-native-speakers.pdf
Peer-review Report	100227-peer-reviews.pdf
Scientific Misconduct Check	100227-scientific-misconduct-check.png
Scientific Editor Work List	100227-scientific-editor-work-list.pdf
CrossCheck Report	100227-crosscheck-report.pdf