| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
High expression of stearoyl-coenzyme A desaturase in colorectal cancer oncogenic functions and its potential as a therapeutic target
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Wei Wang, Wan-Ying Huang, Kai Qin, Da-Tong Zeng, Zu-Yuan Chen, Bang-Teng Chi, Yu-Xing Tang, Qi Li, Bin Li, Dong-Ming Li, Rong-Quan He, Wei-Jian Huang, Gang Chen, Rui-Xue Tang and Zhen-Bo Feng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2020QH185 |
| Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital |
QYPY2020NSFC0803 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
Z20210442 |
|
| Corresponding Author |
Zhen-Bo Feng, PhD, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com |
| Key Words |
Colorectal cancer; Stearoyl-coenzyme A desaturase; Nitidine chloride; Molecular docking; Standardized mean difference |
| Core Tip |
Stearoyl-coenzyme A desaturase (SCD) is markedly upregulated in colorectal cancer (CRC), highlighting its role as an oncogenic factor and suggesting its potential as a therapeutic target. Our extensive analysis across multiple centers reveals that the increased SCD expression is closely associated with CRC progression and vascular invasion. Nitidine chloride, targeting SCD, shows promise in CRC treatment by potentially modulating the cell cycle. This study provides robust statistical evidence supporting SCD as a critical factor in CRC pathology and a viable target for effective therapeutic strategies. |
| Publish Date |
2025-01-22 09:25 |
| Citation |
<p>Wang XW, Huang WY, Qin K, Zeng DT, Chen ZY, Chi BT, Tang YX, Li Q, Li B, Li DM, He RQ, Huang WJ, Chen G, Tang RX, Feng ZB. High expression of stearoyl-coenzyme A desaturase in colorectal cancer oncogenic functions and its potential as a therapeutic target. <i>World J Gastrointest Surg</i> 2025; 17(2): 100237</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i2/100237.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i2.100237 |
