Publication Name	World Journal of Gastroenterology
Manuscript ID	100271
Country	China

Received	2024-08-20 02:30
Peer-Review Started	2024-08-12 04:03
To Make the First Decision
Return for Revision	2024-11-26 05:50
Revised	2024-12-08 07:01
Second Decision	2025-01-13 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-13 06:17
Articles in Press	2025-01-13 06:17
Publication Fee Transferred	2024-12-10 04:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-10 02:14
Publish the Manuscript Online	2025-02-18 09:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Qin, Rui-Ya Zhang, Yu Zhang, Yi-Qing Zhao, Hai-Feng Hao and Jun-Ping Wang
ORCID	Author(s) ORCID Number Rui-Ya Zhang http://orcid.org/0000-0002-5925-8909 Jun-Ping Wang http://orcid.org/0000-0002-9360-4131
Funding Agency and Grant Number	Funding Agency Grant Number Provincial Key Cultivation Laboratory for Digestive Disease Research, Shanxi Province’s “Si Ge Yi Pi” Science and Technology Driven Medical Innovation Project 2021SYS13, 2020SYS13 and 2021MX03
Corresponding Author	Jun-Ping Wang, MD, Professor, Department of Gastroenterology, Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, No. 29 Shuangtasi Street, Taiyuan 030012, Shanxi Province, China. wangjp8396@sxmu.edu.cn
Key Words	Ulcerative colitis; Panax ginseng; Network pharmacology; Panaxadiol; MAPK; NF-κB; AMPK; NRF2
Core Tip	Panax ginseng is widely used to treat ulcerative colitis (UC) and known for its therapeutic efficacy. However, the specific components and mechanisms underlying its action require further clarification. Using network pharmacology analysis, we identified the main components of Panax ginseng in treating UC, with panaxadiol (PD) emerging as the most abundant and potentially critical component. Next, we validated the role of PD in a mouse model of dextran sulfate sodium-induced colitis. The results demonstrated that PD effectively alleviates colitis and helps repair the intestinal barrier, partly via modulation of the MAPK/NF-кB and AMPK/NRF2/NQO1 signaling pathways.
Publish Date	2025-02-18 09:00
Citation	<p>Qin Y, Zhang RY, Zhang Y, Zhao YQ, Hao HF, Wang JP. Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis. <i>World J Gastroenterol</i> 2025; 31(9): 100271</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i9/100271.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i9.100271

Full Article (PDF)	WJG-31-100271-with-cover.pdf
The ARRIVE Guidelines	100271-The-ARRIVE-Guidelines.pdf
Manuscript File	100271_Auto_Edited_082805.docx
Answering Reviewers	100271-answering-reviewers.pdf
Audio Core Tip	100271-audio.wav
Biostatistics Review Certificate	100271-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100271-conflict-of-interest-statement.pdf
Copyright License Agreement	100271-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100271-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	100271-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	100271-non-native-speakers.pdf
Peer-review Report	100271-peer-reviews.pdf
Scientific Misconduct Check	100271-scientific-misconduct-check.png
Scientific Editor Work List	100271-scientific-editor-work-list.pdf
CrossCheck Report	100271-crosscheck-report.pdf