Publication Name	World Journal of Psychiatry
Manuscript ID	100297
Country	China

Received	2024-08-12 23:10
Peer-Review Started	2024-08-12 23:10
To Make the First Decision
Return for Revision	2024-10-23 10:50
Revised	2024-10-31 21:20
Second Decision	2024-11-21 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-21 07:59
Articles in Press	2024-11-21 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-24 12:16
Typeset the Manuscript	2024-12-02 02:32
Publish the Manuscript Online	2024-12-18 08:36

ISSN	2220-3206 (online)
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Category	Psychology, Clinical
Manuscript Type	Editorial
Article Title	Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap
Manuscript Source	Invited Manuscript
All Author List	Xiao-Man Chen, Shuo Zhang, Shi-Qi Gao and Michael Xu
ORCID	Author(s) ORCID Number Xiao-Man Chen http://orcid.org/0009-0003-6832-8723 Shuo Zhang http://orcid.org/0000-0002-4367-0026 Shi-Qi Gao http://orcid.org/0009-0006-0666-2736
Funding Agency and Grant Number
Corresponding Author	Shuo Zhang, Assistant Professor, MD, PhD, Department of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. flybird31025@163.com
Key Words	Epilepsy; Interleukin-6; Neuropsychiatric comorbidities; Depression; Tocilizumab; Neuroinflammation; Interleukin-6 receptor blockade
Core Tip	Interleukin (IL)-6 homeostasis is crucial to the pathophysiology of epilepsy and its associated neuropsychiatric comorbidities, suggesting its potential utility as a biomarker for disease activity. Therapeutic strategies aimed at inhibiting IL-6 signaling through receptor blockade represent a novel and promising approach for treating epilepsy and its neuropsychiatric manifestations. Elucidating the mechanisms by which IL-6 modulates epilepsy and its neuropsychiatric comorbidities can provide valuable insights into potential therapeutic targets, thereby enhancing patient outcomes.
Publish Date	2024-12-18 08:36
Citation	<p>Chen XM, Zhang S, Gao SQ, Xu M. Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap. <i>World J Psychiatry</i> 2025; 15(1): 100297</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i1/100297.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i1.100297

Full Article (PDF)	WJP-15-100297-with-cover.pdf
Manuscript File	100297_Auto_Edited_104136.docx
Answering Reviewers	100297-answering-reviewers.pdf
Audio Core Tip	100297-audio.mp3
Conflict-of-Interest Disclosure Form	100297-conflict-of-interest-statement.pdf
Copyright License Agreement	100297-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100297-non-native-speakers.pdf
Peer-review Report	100297-peer-reviews.pdf
Scientific Misconduct Check	100297-scientific-misconduct-check.png
Scientific Editor Work List	100297-scientific-editor-work-list.pdf
CrossCheck Report	100297-crosscheck-report.pdf