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Articles Published Processes
4/23/2025 3:33:30 AM | Browse: 5 | Download: 15
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Received |
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2024-08-14 06:48 |
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Peer-Review Started |
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2024-08-14 06:48 |
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To Make the First Decision |
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Return for Revision |
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2024-11-18 08:57 |
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Revised |
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2024-11-29 09:36 |
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Second Decision |
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2025-03-14 01:11 |
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Accepted by Journal Editor-in-Chief |
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2025-03-17 05:48 |
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Accepted by Executive Editor-in-Chief |
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2025-03-24 06:12 |
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Articles in Press |
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2025-03-24 06:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-14 02:22 |
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Publish the Manuscript Online |
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2025-04-23 03:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Yu Zhang, Si-Miao Liu, Han-Bi Wang and Cheng-Yan Deng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
2022-PUMCH-B-080, 2022-PUMCH-C-064 |
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| Corresponding Author |
Cheng-Yan Deng, MD, Professor, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. chydmd@hotmail.com |
| Key Words |
Endometrial epithelial cells; Exosomes; MiR-137-3p; Ubiquitin protein ligase E3C; Signal transducer and activator of transcription 3; Human umbilical cord mesenchymal stem cells |
| Core Tip |
This study uncovers that under hypoxic conditions, exosomal miR-137-3p, by targeting UBE3C, activates signal transducer and activator of transcription 3, thereby enhancing the migration and differentiation of human umbilical cord mesenchymal stem cells (hucMSCs) into endometrial epithelial cells. Through miRNA sequencing and RT-qPCR validation, it was observed that miR-137-3p is significantly upregulated in hucMSCs when co-cultured with endometrial epithelial cells. Additionally, exosome-based therapeutic system was established to evaluate the role of hucMSCs overexpressing miR-137-3p in therapeutic applications. This discovery offers novel insights into cell therapy under hypoxic environments. |
| Publish Date |
2025-04-23 03:33 |
| Citation |
<p>Zhang WY, Liu SM, Wang HB, Deng CY. Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia. <i>World J Stem Cells</i> 2025; 17(4): 100359</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i4/100359.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i4.100359 |
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