Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	100386
Country	Bahrain

Received	2024-08-22 06:59
Peer-Review Started	2024-08-14 21:00
To Make the First Decision
Return for Revision	2024-09-25 06:54
Revised	2024-10-08 13:57
Second Decision	2024-11-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-12 09:09
Articles in Press	2024-11-12 09:09
Publication Fee Transferred	2024-11-13 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-16 03:41
Publish the Manuscript Online	2024-12-20 07:07

ISSN	2219-2808 (online)
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Category	Allergy
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical, laboratory, and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children
Manuscript Source	Invited Manuscript
All Author List	Hasan M Isa, Marwa J Abdulnabi, Nawra S Naser, Fatema N Lahmda, Noor M AlAnsari, Zahra H Isa and Afaf M Mohamed
ORCID	Author(s) ORCID Number Hasan M Isa http://orcid.org/0000-0001-6022-5576 Marwa J Abdulnabi http://orcid.org/0009-0003-3631-9769 Nawra S Naser http://orcid.org/0009-0009-2062-9096 Fatema N Lahmda http://orcid.org/0009-0005-1510-6785 Noor M AlAnsari http://orcid.org/0009-0004-0998-1682 Zahra H Isa http://orcid.org/0009-0003-0919-2600 Afaf M Mohamed http://orcid.org/0000-0003-2376-8998
Funding Agency and Grant Number
Corresponding Author	Hasan M Isa, Associate Professor, Department of Pediatrics, Salmaniya Medical Complex, 2904 Al Salmaniya Area, PO Box 12, Manama 26671, Bahrain. halfaraj@hotmail.com
Key Words	Children; Milk allergy; Immunoglobulin E; Breastfeeding; Infant formula; Bahrain
Core Tip	The prevalence of cow’s milk protein allergy (CMPA) in children in Bahrain and differences between immunoglobulin E (IgE)–mediated and non-IgE–mediated allergies have not been studied previously. In this retrospective cohort study, we found that CMPA, commonly the non-IgE–mediated type, affects 2% of children among those visiting outpatient pediatric gastroenterology clinics. IgE-mediated CMPA presents with more severe symptoms and physical findings than non-IgE–mediated CMPA. Despite being common, CMPA diagnosis depends on the clinical presentation. Amino acid-based formulas are frequently prescribed, whereas exclusive breastfeeding and maternal dietary restrictions are underutilized. Therefore, breastfeeding children with CMPA should be encouraged.
Publish Date	2024-12-20 07:07
Citation	<p>Isa HM, Abdulnabi MJ, Naser NS, Lahmda FN, AlAnsari NM, Isa ZH, Mohamed AM. Clinical, laboratory, and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children. <i>World J Clin Pediatr</i> 2025; 14(1): 100386</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i1/100386.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i1.100386

Full Article (PDF)	WJCP-14-100386-with-cover.pdf
STROBE Statement	100386-STROBE-statement.pdf
Manuscript File	100386_Auto_Edited_015321.docx
Answering Reviewers	100386-answering-reviewers.pdf
Audio Core Tip	100386-audio.m4a
Biostatistics Review Certificate	100386-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100386-conflict-of-interest-statement.pdf
Copyright License Agreement	100386-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	100386-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	100386-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	100386-non-native-speakers.pdf
Supplementary Material	100386-supplementary-material.pdf
Peer-review Report	100386-peer-reviews.pdf
Scientific Misconduct Check	100386-scientific-misconduct-check.png
Scientific Editor Work List	100386-scientific-editor-work-list.pdf
CrossCheck Report	100386-crosscheck-report.pdf