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Articles Published Processes
12/30/2024 9:47:16 AM | Browse: 82 | Download: 659
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Received |
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2024-08-15 05:37 |
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Peer-Review Started |
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2024-08-19 00:19 |
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First Decision by Editorial Office Director |
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2024-09-18 05:46 |
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Return for Revision |
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2024-09-18 05:46 |
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Revised |
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2024-10-02 04:10 |
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Publication Fee Transferred |
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2024-11-25 13:08 |
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Second Decision by Editor |
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2024-11-08 10:53 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-25 10:31 |
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Articles in Press |
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2024-11-25 10:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-20 02:02 |
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Publish the Manuscript Online |
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2024-12-30 09:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rasha A Mansouri, Esam M Aboubakr, Huda F Alshaibi and Adel M Ahmed |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia |
IF2/PSAU/2022/03/23339 |
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| Corresponding Author |
Esam M Aboubakr, Associate Professor, PhD, Department of Pharmacology and Toxicology, Faculty of Pharmacy-South Valley University, Qena- South valley university, Qena 83523, Egypt. esam_pharma@svu.edu.eg |
| Key Words |
L-arginine administration; Type 2 diabetes; Cardiac muscle injury; Oxidative stress; Inflammatory cytokines; Desmin disruption |
| Core Tip |
L-arginine is commonly used amino acid with many physiological effects, but its safety and pharmacological effects are not fully understood and still controversial. This study found that a dose of 0.5 g/kg of L-arginine appears to be the highest dose that can be safely administered without producing cardiac damage in diabetic rats. However, doses of 1 g/kg or higher can worsen myocardial damage by increasing blood glucose levels, inflammation, and oxidative stress. L-arginine can also reduce body weight and improve lipid levels in rats, but these benefits do not outweigh the injurious effects of high doses on the cardiac muscle. |
| Publish Date |
2024-12-30 09:47 |
| Citation |
Mansouri RA, Aboubakr EM, Alshaibi HF, Ahmed AM. L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption. World J Diabetes 2025; 16(2): 100395 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i2/100395.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i2.100395 |
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