Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	100412
Country	Malaysia

Received	2024-08-15 13:41
Peer-Review Started	2024-08-15 13:48
To Make the First Decision
Return for Revision	2024-09-19 03:32
Revised	2024-09-30 02:33
Second Decision	2024-10-10 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-10 07:22
Articles in Press	2024-10-10 07:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-19 01:01
Typeset the Manuscript	2024-10-23 01:04
Publish the Manuscript Online	2024-10-30 03:20

ISSN	1948-5190 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Post prandial gastrin seventeen level is a useful dynamic marker for atrophic gastritis
Manuscript Source	Invited Manuscript
All Author List	Huck-Joo Tan and Eunice Zhi-Yi Tan
ORCID	Author(s) ORCID Number Huck-Joo Tan http://orcid.org/0009-0002-9727-4835
Funding Agency and Grant Number
Corresponding Author	Huck-Joo Tan, MD, Department of Gastroenterology and Hepatology, Cengild GI Medical Center, 7 Jalan Kerinchi, Bangsar South, Kuala Lumpur 50490, Malaysia. hucktanhj@gmail.com
Key Words	Atrophic gastritis; Pepsinogen; Gastrin-seventeen; Gastric cancer; Biomarkers
Core Tip	Atrophic gastritis and intestinal metaplasia are classified as premalignant conditions. Serological markers such as pepsinogen and gastrin-seventeen (G-17) have been proposed as useful surrogate biomarkers for gastric mucosa. Previous studies have shown that patients with atrophic corpus gastritis have low pepsinogen-I and pepsinogen ratio values, but high G-17 levels, whereas patients with atrophic antral gastritis have low G-17 levels. Low serum levels of pepsinogen and G-17 are predictive of extensive gastric atrophy with a high risk of early gastric cancer. Several international consensus guidelines, such as the management of epithelial precancerous conditions and lesions in the stomach I and II consensus, the Maastricht VI/Florence Consensus, and the Kyoto consensus, recommend using pepsinogen serology to identify patients with atrophic gastritis for endoscopy. In the current study by Kotelevets et al, assessing the effectiveness of serological markers in gastric mucosal atrophy, the sensitivity of postprandial gastrin levels can be improved with a specific cut-off level. Postprandial G-17 levels are also good dynamic markers for the regression of atrophic gastritis after treatment. Therefore, serum biomarkers may provide valuable insights into the progression or regression of atrophic gastritis.
Publish Date	2024-10-30 03:20
Citation	<p>Tan HJ, Tan EZY. Post prandial gastrin seventeen level is a useful dynamic marker for atrophic gastritis. <i>World J Gastrointest Endosc</i> 2024; 16(11): 623-626</p>
URL	https://www.wjgnet.com/1948-5190/full/v16/i11/623.htm
DOI	https://dx.doi.org/10.4253/wjge.v16.i11.623

Full Article (PDF)	WJGE-16-623-with-cover.pdf
Manuscript File	100412_Auto_Edited_005234.docx
Answering Reviewers	100412-answering-reviewers.pdf
Audio Core Tip	100412-audio.mp3
Conflict-of-Interest Disclosure Form	100412-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	100412-non-native-speakers.pdf
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Scientific Editor Work List	100412-scientific-editor-work-list.pdf
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CrossCheck Report	100412-crosscheck-report.pdf