| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Establishment and characterization of a new human gallbladder cancer cell line, OCUG-2
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Qiang Wang, Canfeng Fan, Gen Tsujio, Takashi Sakuma, Koji Maruo, Yurie Yamamoto, Daiki Imanishi, Kyoka Kawabata, Hinano Nishikubo, Saki Kanei, Rika Aoyama, Syuhei Kushiyama, Masaichi Ohira and Masakazu Yashiro |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Masakazu Yashiro, Associate Professor, MD, PhD, Department of Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-0051, Japan. i21496f@omu.ac.jp |
| Key Words |
Gallbladder cancer; Cell line; Insulin-like growth factor 1 receptor; Molecular target; Mouse model |
| Core Tip |
We established a new gallbladder cancer (GBC) cell line derived from a metastatic peritoneal implant of GBC. These cells, named OCUG-2, showed adhesive growth with a dendritic morphology. Doubling time of OCUG-2 cells was 30 hours. OCUG-2 cells were positive for insulin-like growth factor 1 receptor (IGF1R), and an IGF1R inhibitor reduced the proliferation of OCUG-2 cells. Immunohistochemistry found IGF1R positivity in 18 of 34 cases of GBC, and IGF1R expression was associated with poor prognosis. These findings suggest that IGF1R may be a promising target for GBC and OCUG-2 might be useful for analysis of GBC. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Wang Q, Fan C, Tsujio G, Sakuma T, Maruo K, Yamamoto Y, Imanishi D, Kawabata K, Nishikubo H, Kanei S, Aoyama R, Kushiyama S, Ohira M, Yashiro M. Establishment and characterization of a new human gallbladder cancer cell line, OCUG-2. <i>World J Exp Med</i> 2025; 15(2): 100443</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/100443.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.100443 |
