Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100463
Country	China

Received	2024-08-17 02:38
Peer-Review Started	2024-08-17 02:38
To Make the First Decision
Return for Revision	2024-10-23 01:36
Revised	2024-11-04 12:14
Second Decision	2024-12-16 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-16 07:40
Articles in Press	2024-12-16 07:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-22 03:55
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Editorial
Article Title	Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors
Manuscript Source	Invited Manuscript
All Author List	Yuan Liu and Xiao-Feng Li
ORCID	Author(s) ORCID Number Xiao-Feng Li http://orcid.org/0000-0001-5155-8475
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82370569 Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515012647 Key Program for Science and Technology Projects of Social Development in Zhuhai 2220004000249
Corresponding Author	Xiao-Feng Li, PhD, Professor, Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, No. 52 Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China. zdwylxf@163.com
Key Words	Gastrointestinal stromal tumors; KIT mutation; Platelet-derived growth factor receptor alpha mutation; Wild-type gastrointestinal stromal tumor; Tyrosine kinase inhibitors; Familial gastrointestinal stromal tumor syndromes; Molecular characteristics; Targeted therapy
Core Tip	The management of familial gastrointestinal stromal tumors (GISTs) depends on the conduct of genetic surveillance, with early screening for first-degree relatives being essential. Current treatment strategies are essentially the same as those used for sporadic GISTs, primarily consisting of surgery and tyrosine kinase inhibitor targeted therapy. For familial GISTs, additional experience and evidence are required for treatment, prognosis, and monitoring; therefore, it is advisable to adopt more proactive therapeutic and follow-up strategies.
Publish Date	2025-02-14 10:33
Citation	<p>Liu Y, Li XF. Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors. <i>World J Gastrointest Oncol</i> 2025; 17(3): 100463</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/100463.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.100463

Full Article (PDF)	WJGO-17-100463-with-cover.pdf
Manuscript File	100463_Auto_Edited_031751.docx
Answering Reviewers	100463-answering-reviewers.pdf
Audio Core Tip	100463-audio.mp3
Conflict-of-Interest Disclosure Form	100463-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	100463-non-native-speakers.pdf
Peer-review Report	100463-peer-reviews.pdf
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Scientific Editor Work List	100463-scientific-editor-work-list.pdf
CrossCheck Report	100463-crosscheck-report.pdf