Publication Name	World Journal of Gastroenterology
Manuscript ID	100473
Country	China

Received	2024-08-17 14:38
Peer-Review Started	2024-08-17 14:38
To Make the First Decision
Return for Revision	2024-09-15 23:35
Revised	2024-09-24 09:45
Second Decision	2024-10-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 06:15
Articles in Press	2024-10-08 06:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-14 15:06
Publish the Manuscript Online	2024-10-23 04:32

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Pharmacology & Pharmacy
Manuscript Type	Letter to the Editor
Article Title	Encapsulating taurine into liposomes: A promising therapeutic for liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Juan Zhang, Xiao-Yi Jiang, Yi-Lin Ma, Fei-Yi Huang and Zheng-Wei Huang
ORCID	Author(s) ORCID Number Zheng-Wei Huang http://orcid.org/0000-0003-2351-7347
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82373800 Guangdong Basic and Applied Basic Research Foundation No. 2024A1515011236 General Program of Administration of Traditional Chinese Medicine of Guangdong Province No. 20241071
Corresponding Author	Zheng-Wei Huang, PhD, Associate Professor, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511443, Guangdong Province, China. huangzhengw@jnu.edu.cn
Key Words	Taurin; Liposome; Liver fibrosis; Targeted therapy; Nanoparticle delivery systems; Hepatic stellate cells
Core Tip	Nanoparticle delivery systems are effective for delivering taurine (Tau). The nanoarchitecture of liposomes includes a water zone and a lipid membrane to accommodate hydrophilic and hydrophobic drugs, respectively. Tau is a hydrophilic molecule with high water solubility, and it is expected to be loaded into the water zone. In theory, hepatic stellate cells (HSCs) may be targeted by Tau-incorporated liposomes via two mechanisms: Passive targeting and active targeting. Active targeting is more robust as it takes advantage of the unique features of the lesion site. Based on a formulation for common liposomes (lecithin plus cholesterol), Tau-based therapeutics was proposed to treat liver fibrosis as follows: A targetable liposome was fabricated through the combination of common lecithin and cholesterol, along with modified lecithin or cholesterol with HSC targetability. Tau was dispersed into the water zone of this liposomal system.
Publish Date	2024-10-23 04:32
Citation	<p>Zhang XJ, Jiang XY, Ma YL, Huang FY, Huang ZW. Encapsulating taurine into liposomes: A promising therapeutic for liver fibrosis. <i>World J Gastroenterol</i> 2024; 30(41): 4509-4513</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i41/4509.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i41.4509

Full Article (PDF)	WJG-30-4509-with-cover.pdf
Manuscript File	100473_Auto_Edited_061600.docx
Answering Reviewers	100473-answering-reviewers.pdf
Audio Core Tip	100473-audio.m4a
Conflict-of-Interest Disclosure Form	100473-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	100473-non-native-speakers.pdf
Peer-review Report	100473-peer-reviews.pdf
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Scientific Editor Work List	100473-scientific-editor-work-list.pdf
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CrossCheck Report	100473-crosscheck-report.pdf