Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100505
Country	Greece

Received	2024-08-18 11:42
Peer-Review Started	2024-08-18 11:42
To Make the First Decision
Return for Revision	2024-09-24 12:46
Revised	2024-10-16 16:55
Second Decision	2024-11-12 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-12 07:43
Articles in Press	2024-11-12 07:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-18 11:51
Typeset the Manuscript	2024-11-21 00:45
Publish the Manuscript Online	2025-01-18 08:11

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Anticipation for hepatic arterial infusion chemotherapy in the treatment of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Grigorios Christodoulidis, Dimitra Bartzi and Konstantinos E Koumarelas
ORCID	Author(s) ORCID Number Grigorios Christodoulidis http://orcid.org/0000-0003-3413-0666 Konstantinos E Koumarelas http://orcid.org/0000-0002-5614-4770
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, PhD, Department of General Surgery, University Hospital of Larissa, Memou Makri 39, Larissa 41335, Greece. gregsurg@yahoo.gr
Key Words	Hepatocellular carcinoma; Hepatic arterial infusion chemotherapy; Targeted therapy; Challenges; Safety; Advantages
Core Tip	Hepatic arterial infusion chemotherapy (HAIC) is emerging as a pivotal targeted therapy for advanced hepatocellular carcinoma. By tailoring clinical trials, HAIC particularly when combined with immune checkpoint inhibitors like lenvatinib and programmed cell death-1 inhibitors, significantly enhances overall survival and progression-free survival compared to traditional systemic chemotherapy. These combination therapies not only improve response rates and disease control but also maintain manageable side effects, highlighting their therapeutic potential. Longing for future research which should aim to optimize HAIC protocols and investigate novel therapeutic combinations to further advance treatment outcomes for hepatocellular carcinoma patients.
Publish Date	2025-01-18 08:11
Citation	<p>Christodoulidis G, Bartzi D, Koumarelas KE. Anticipation for hepatic arterial infusion chemotherapy in the treatment of hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(2): 100505</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i2/100505.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i2.100505

Full Article (PDF)	WJGO-17-100505-with-cover.pdf
Manuscript File	100505_Auto_Edited_030846.docx
Answering Reviewers	100505-answering-reviewers.pdf
Audio Core Tip	100505-audio.m4a
Conflict-of-Interest Disclosure Form	100505-conflict-of-interest-statement.pdf
Copyright License Agreement	100505-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100505-non-native-speakers.pdf
Peer-review Report	100505-peer-reviews.pdf
Scientific Misconduct Check	100505-scientific-misconduct-check.png
Scientific Editor Work List	100505-scientific-editor-work-list.pdf
CrossCheck Report	100505-crosscheck-report.pdf