| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside (acid) analogs for hepatitis B virus
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua-Dong Li, Ya-Nan Liu, Shuang Wu, Xu-Feng Quan, Xiao-Yan Wang, Tian-Dan Xiang, Shu-Meng Li, Ling Xu, Tong Wang, Hua Wang and Xin Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wuhan Science and Technology Bureau Knowledge Innovation Special Foundation of Hubei Province |
2022020801010588 |
| National Key R and D Projects |
2022YFC2305100 |
| National Science and Technology Major Project of China |
92169121 |
|
| Corresponding Author |
Xin Zheng, MD, PhD, Professor, Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. xinz@hust.edu.cn |
| Key Words |
Nonalcoholic fatty liver disease; Chronic hepatitis B; Nucleoside analogues; Antiviral therapy; Virological response |
| Core Tip |
The effect of nonalcoholic fatty liver disease (NAFLD) on the antiviral therapy with nucleoside analogues (NAs) in patients with chronic hepatitis B (CHB) is controversial. The aim of this study was to investigate the virological response to first-line NAs antiviral treatment in patients with NAFLD and CHB, through dynamically monitoring virology indicators for 96 weeks, to determine the influence of NAFLD on the efficacy of NAs anti- hepatitis B virus treatment. To our knowledge, this is the first grading study based on HBV baseline viral load that confirms a reduction in virological response to NAs antiviral treatment caused by NAFLD. |
| Publish Date |
2024-11-29 14:50 |
| Citation |
<p>Li HD, Liu YN, Wu S, Quan XF, Wang XY, Xiang TD, Li SM, Xu L, Wang T, Wang H, Zheng X. Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside (acid) analogs for hepatitis B virus. <i>World J Hepatol</i> 2024; 16(12): 1395-1406</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i12/1395.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i12.1395 |
