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Articles Published Processes
4/16/2025 5:36:36 AM | Browse: 113 | Download: 568
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Received |
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2024-08-21 02:08 |
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Peer-Review Started |
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2024-09-04 14:04 |
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First Decision by Editorial Office Director |
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2024-12-11 06:14 |
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Return for Revision |
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2024-12-11 06:14 |
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Revised |
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2024-12-19 10:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-01-02 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-01-02 10:30 |
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Articles in Press |
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2025-01-02 10:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-27 01:53 |
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Publish the Manuscript Online |
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2025-04-16 05:36 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
MiRNA dysregulation in Duchenne muscular dystrophy comorbidities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Subhashree Sivakumar, Archana Rajavel, Venkataraman Viswanathan, Evangeline Ann Daniel, Prakash Gangadaran and NS Raja |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
NS Raja, Assistant Professor, PhD, Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nādu, India. rajan3@srmist.edu.in |
| Key Words |
Duchenne muscular dystrophy; Dystrophin; MiRNA; Autism spectrum disorder; Phosphatase and tensin; Inflammatory response |
| Core Tip |
This study presents a rare case of a ten-year-old boy with Duchenne muscular dystrophy (DMD) coexisting with autism spectrum disorder and epilepsy. By investigating the differential expression of miRNAs, we identified a significant downregulation of miR-132-3p in the DMD patient compared to the comorbid DMD case. This suggests that miR-132-3p downregulation may have contributed to accelerated muscle atrophy through failed silencing of the phosphatase and tensin homolog-mediated apoptotic pathway. Our findings emphasize the importance of studying such rare DMD comorbidities to enhance understanding of disease heterogeneity and improve diagnosis and treatment strategies. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
Sivakumar S, Rajavel A, Viswanathan V, Daniel EA, Gangadaran P, Raja N. MiRNA dysregulation in Duchenne muscular dystrophy comorbidities. World J Exp Med 2025; 15(2): 100548 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/100548.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.100548 |
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