| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi Lan, Heng Zhang, Ze-Yan Chen, Jing Wang, Shi-Chang Zhang, Qing Li, Juan-Yu Ke, Wei Wei, Rong Huang, Xi Tang, Si-Ping Chen, Ting-Ting Huang and Yi-Wen Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wu Jieping Medical Foundation |
320.6750.2021-06-30 |
| Guangdong Basic and Applied Basic Research Foundation |
2019A1515110120 |
| National Natural Science Foundation of China |
82002974 |
|
| Corresponding Author |
Yi-Wen Zhou, PhD, Clinical Laboratory Center, Shenzhen Hospital, Southern Medical University, No. 1333 Xinhu Road, Bao'an District, Shenzhen 518101, Guangdong Province, China. yiwenzhou21@aliyun.com |
| Key Words |
Liver hepatocellular carcinoma; Regulatory T cells; Suppressor of cytokine signaling 2; Immune microenvironment; Tumor metastasis |
| Core Tip |
This study provides novel insights into the role of the suppressor of cytokine signaling 2 (SOCS2) in inhibiting liver hepatocellular carcinoma (LIHC) growth and metastasis by modulating regulatory T-cell (Treg) activity. Through comprehensive bioinformatics analysis and both in vitro and in vivo experiments, we demonstrated that SOCS2 overexpression suppresses Treg cell activity, enhances cancer cell apoptosis, and reduces tumor migration and invasion. These findings highlight SOCS2 as a potential therapeutic target for improving LIHC prognosis by modulating immune responses in the tumor microenvironment. |
| Publish Date |
2025-04-02 10:54 |
| Citation |
<p>Lan X, Zhang H, Chen ZY, Wang J, Zhang SC, Li Q, Ke JY, Wei W, Huang R, Tang X, Chen SP, Huang TT, Zhou YW. Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis. <i>World J Gastroenterol</i> 2025; 31(13): 100566</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i13/100566.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i13.100566 |
