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Articles Published Processes
11/6/2024 9:50:59 AM | Browse: 57 | Download: 140
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Received |
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2024-08-26 05:20 |
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Peer-Review Started |
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2024-09-03 08:57 |
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To Make the First Decision |
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Return for Revision |
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2024-09-18 03:12 |
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Revised |
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2024-09-29 20:38 |
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Second Decision |
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2024-10-14 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-10-14 08:06 |
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Articles in Press |
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2024-10-14 08:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2024-10-16 01:01 |
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Typeset the Manuscript |
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2024-10-17 07:02 |
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Publish the Manuscript Online |
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2024-11-06 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yong-Zhi Zhuang, Li-Quan Tong and Xue-Ying Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Key Research and Development Program of China |
2017YFC1308602 |
| The Research Funds by the Fifth Affiliated Hospital of Harbin Medical University |
2022-002 |
| The Research Funds by the Fifth Affiliated Hospital of Harbin Medical University |
2023-001 |
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| Corresponding Author |
Xue-Ying Sun, MD, PhD, Professor, Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. k.sun@auckland.ac.nz |
| Key Words |
Cholangiocarcinoma; 26S proteasome non-ATPase regulatory subunit 6; Molecular targeted therapies; Proteasome inhibitors; Clustered regularly interspaced short palindromic repeat |
| Core Tip |
Drug therapy of intrahepatic cholangiocarcinoma (iCCA) poses a big challenge and seeking potential molecular targets is being actively pursued. 26S proteasome non-ATPase regulatory subunit 6 (PSMD6) gene is essential for cell proliferation and PSMD6 protein was overexpressed in iCCA tissues, indicating that PSMD6 may play a promoting role in iCCA. However, this study has several limitations and defects, such as the lack of detailed information of CRISPR knockout screening, in vivo experiments, and exploration of plausible mechanisms, reducing the significance of the results. Further studies are required to verify the role of PSMD6 as a molecular target for iCCA. |
| Publish Date |
2024-11-06 09:50 |
| Citation |
<p>Zhuang YZ, Tong LQ, Sun XY. Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma? <i>World J Hepatol</i> 2024; 16(11): 1219-1224</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i11/1219.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i11.1219 |
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