Publication Name	World Journal of Gastroenterology
Manuscript ID	10066
Country	China

Received	2014-03-11 14:32
Peer-Review Started	2014-03-11 14:42
To Make the First Decision	2014-03-27 21:09
Return for Revision	2014-03-31 10:13
Revised	2014-05-08 00:00
Second Decision	2014-05-26 21:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-26 21:58
Articles in Press	2014-05-26 22:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-30 15:41
Typeset the Manuscript	2014-09-12 15:51
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of Nrf2 in chronic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Tang, Yong-Fang Jiang, Murugavel Ponnusamy and Mamadou Diallo
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2011 (1318) Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2012 (1493) Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2013 (1132)
Corresponding Author	Yong-Fang Jiang, MD, PhD, Liver Diseases Research Center, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha 410011, Hunan Province, China. jiangyongfang@hotmail.com
Key Words	Nuclear erythroid 2-related factor 2; Chronic liver disease; Oxidative stress; Reactive oxygen species; Hepatic injury; Hepatic protection
Core Tip	Chronic liver disease is associated with an imbalance, comprising increased reactive oxygen species and decreased net antioxidant activity. Oxidative stress plays an important role in the pathophysiological changes of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) can activate cytoprotective genes and has a crucial role against oxidative stress to protect hepatic cells from oxidative damage. This article focuses on the activation the Nrf2-mediated antioxidant response, which prevents the progression of chronic liver disease and presents new treatment opportunities. Accordingly, integrative therapeutic strategies including Nrf2 activators have great potential as therapeutic agents against oxidative stress during chronic liver injuries.
Publish Date	2014-10-01 20:25
Citation	Tang W, Jiang YF, Ponnusamy M, Diallo M. Role of Nrf2 in chronic liver disease. World J Gastroenterol 2014; 20(36): 13079-13087
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/13079.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.13079

Full Article (PDF)	WJG-20-13079.pdf
Full Article (Word)	WJG-20-13079.doc
Manuscript File	10066-Review.doc
Answering Reviewers	10066-Answering reviewers.pdf
Copyright License Agreement	10066-Copyright Assignment.pdf
Peer-review Report	10066-Peer review.pdf
Scientific Misconduct Check	10066-CrossCheck.jpg
Scientific Editor Work List	10066-Scientific editor work list.pdf