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Articles Published Processes
11/30/2024 3:48:51 AM | Browse: 94 | Download: 456
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Received |
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2024-08-22 16:12 |
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Peer-Review Started |
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2024-08-22 16:12 |
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First Decision by Editorial Office Director |
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2024-10-09 03:14 |
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Return for Revision |
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2024-10-09 03:14 |
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Revised |
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2024-10-22 18:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-11-13 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-13 08:30 |
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Articles in Press |
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2024-11-13 08:30 |
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Edit the Manuscript by Language Editor |
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2024-11-18 17:51 |
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Typeset the Manuscript |
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2024-11-21 08:33 |
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Publish the Manuscript Online |
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2024-11-30 03:48 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Yu Zhao, Pei-Li Luo, Xia Guo and Zheng-Wei Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82104070 |
| Young Talents Program for Discipline Development of Jinan University |
2024QNGG077 |
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| Corresponding Author |
Zheng-Wei Huang, Assistant Professor, PhD, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511436, Guangdong Province, China. huangzhengw@jnu.edu.cn |
| Key Words |
Polycytosine RNA-binding protein 1; Protein nanoparticle; Osteoblast; Ferroptosis |
| Core Tip |
We propose using PCBP1-loaded protein nanoparticles to treat type 2 diabetic osteoporosis (T2DOP). While PCBP1 is an active pharmaceutical ingredient due to its druggability and small size, current delivery strategies ineffectively preserve its activity. Intravenous injections may be more suitable because they infuse PCBP1 into circulation without mucosal penetration. Moreover, coating PCBP1 with protein can prevent hydrolysis and oxidation; protein nanoparticles are appropriate vesicles as they are also hydrophilic. Additionally, protein materials react with water and oxygen, thereby protecting PCBP1 function. Furthermore, injection-grade PCBP1 and the large-scale production of protein nanoparticles must be investigated to meet pharmaceutical standards. |
| Publish Date |
2024-11-30 03:48 |
| Citation |
Zhao ZY, Luo PL, Guo X, Huang ZW. Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one. World J Diabetes 2025; 16(1): 100675 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i1/100675.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i1.100675 |
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