Publication Name	World Journal of Hepatology
Manuscript ID	100677
Country	China

Received	2024-08-26 05:15
Peer-Review Started	2024-09-06 00:49
To Make the First Decision
Return for Revision	2024-09-25 10:02
Revised	2024-10-14 14:47
Second Decision	2024-10-29 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 11:17
Articles in Press	2024-10-29 11:17
Publication Fee Transferred	2024-11-04 10:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-22 01:43
Publish the Manuscript Online	2024-11-29 14:50

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Jin Zhu, Yan Zhang, Yao Rao, Yong Jiang, Yong-Gang Liu, Jian-Zhou Li, Jia-Qi Yuan, Ying Zhao, Wen-Wen Zheng, Lin Ma, Chun-Yan Wang and Jia Li
ORCID	Author(s) ORCID Number Yu-Jin Zhu http://orcid.org/0000-0003-3332-9606 Yan Zhang http://orcid.org/0009-0009-8587-0147 Yao Rao http://orcid.org/0000-0001-9454-0785 Yong Jiang http://orcid.org/0000-0001-7402-5129 Yong-Gang Liu http://orcid.org/0000-0001-6165-564X Ying Zhao http://orcid.org/0009-0008-1148-4238 Wen-Wen Zheng http://orcid.org/0009-0003-2673-9284 Lin Ma http://orcid.org/0009-0007-5899-2806 Chun-Yan Wang http://orcid.org/0000-0002-1074-1537 Jia Li http://orcid.org/0000-0003-0100-417X
Funding Agency and Grant Number
Corresponding Author	Chun-Yan Wang, MD, Chief Physician, Department of Gastroenterology, Clinical School of the Second People's Hospital, No. 7 Sudi South Road, Nankai District, Tianjin 300110, China. wangchunyan123@tmu.edu.cn
Key Words	Nonalcoholic fatty liver disease; Liver pathology; Autoantibody; Autoimmunity; Clinical indicator
Core Tip	Based on biopsy results, we divided 104 patients into three groups for a retrospective cohort study to assess the immune phenomena in patients with nonalcoholic fatty liver disease (NAFLD). Final discovery: NAFLD patients were positive for several autoantibodies. ANA is the most common antibody in NAFLD patients. Portal enlargement was the most common alteration. The incidences of limiting plate disruption and small bile duct hyperplasia are high in patients with NAFLD-related cirrhosis. Some patients had hepatocellular rosettes and were positive for antibodies. These findings indicate that autoimmune phenomena may be more pronounced in patients with NAFLD-related cirrhosis.
Publish Date	2024-11-29 14:50
Citation	<p>Zhu YJ, Zhang Y, Rao Y, Jiang Y, Liu YG, Li JZ, Yuan JQ, Zhao Y, Zheng WW, Ma L, Wang CY, Li J. Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology. <i>World J Hepatol</i> 2024; 16(12): 1407-1416</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i12/1407.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i12.1407

Full Article (PDF)	WJH-16-1407-with-cover.pdf
STROBE Statement	100677-STROBE-statement.pdf
Manuscript File	100677_Auto_Edited_033933.docx
Answering Reviewers	100677-answering-reviewers.pdf
Audio Core Tip	100677-audio.mp3
Biostatistics Review Certificate	100677-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100677-conflict-of-interest-statement.pdf
Copyright License Agreement	100677-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	100677-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	100677-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	100677-non-native-speakers.pdf
Peer-review Report	100677-peer-reviews.pdf
Scientific Misconduct Check	100677-scientific-misconduct-check.png
Scientific Editor Work List	100677-scientific-editor-work-list.pdf
CrossCheck Report	100677-crosscheck-report.pdf