| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
H M C Shantha Kumara, Poppy Addison, Xiao-Hong Yan, Anuj Raj Sharma, Neil Mitra, Hansani N Angammana, Yanni Hedjar, Yi-Ru Chen, Vesna Cekic and Whelan L Richard |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Thompson Family Foundation |
|
|
| Corresponding Author |
Whelan L Richard, FACS, MD, Professor, Division of Colon and Rectal Surgery, Department of Surgery, Lenox Hill Hospital, Northwell Health, 1421 Third Avenue - Suite PH, New York, NY 10028, United States. rwhelan1@northwell.edu |
| Key Words |
Effects of surgery; Plasma extracellular cold-inducible RNA-binding Protein levels; Colorectal resection; Colorectal cancer; Angiogenesis |
| Core Tip |
Previous investigations from our team have uncovered that the concentrations of twelve distinct plasma proteins implicated in angiogenesis and wound healing processes exhibit elevated levels compared to pre-operative baselines for a period ranging from 2 to 5 weeks following minimally invasive colorectal cancer resection (MICR) surgery. This group includes essential proangiogenic vascular endothelial growth factor, placental growth factor, angiopoietin-2, matrix metalloproteinase 2, 3 and 7 and inflammation induced Interleukin 8 and monocyte chemo-attractant protein-1 (MCP-1). MCP-1 is believed to facilitate angiogenesis by attracting monocytes and macrophages that produce proangiogenic proteins, as well as endothelial cells, to sites of injury. Our findings have substantiated that plasma collected during the second and third weeks post-MICR possesses the capacity to stimulate endothelial cell proliferation, invasion, and migration, which are essential prerequisites for neovascularization. This study, investigating perioperative plasma extracellular cold-inducible RNA-binding protein (eCIRP) levels in the context of MICR, evaluated six postoperative time points and unveiled that blood levels remain significantly elevated above preoperative baseline for a month after surgery. eCIRP and acts as a damage-associated molecular pattern molecule that promotes an inflammatory response (including TNF-α, IL-6 and HMGB production in macrophages, neutrophils, lymphocytes and dendritic cells. Elevated levels of eCIRP together with other elevated angiogenic proteins including T cell immunoglobulin and mucin domain-3 and MCP-1 may enhance macrophage activity and promote immune tolerance, potentially facilitating tumor growth and progression. |
| Publish Date |
2025-03-25 16:19 |
| Citation |
<p>Shantha Kumara HMC, Addison P, Yan XH, Sharma AR, Mitra N, Angammana HN, Hedjar Y, Chen YR, Cekic V, Richard WL. Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases. <i>World J Gastrointest Oncol</i> 2025; 17(4): 100678</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i4/100678.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i4.100678 |
