Category |
Urology & Nephrology |
Manuscript Type |
Observational Study |
Article Title |
Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel
|
Manuscript Source |
Invited Manuscript |
All Author List |
Takumi Endo, Naoto Kamiya, Hiroyoshi Suzuki, Ryo Oka, Fang-Ching Lee, Takanobu Utsumi, Masashi Yano, Shuichi Kamijima, Koji Kawamura, Takashi Imamoto and Tomohiko Ichikawa |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan |
22591761 |
Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan |
23791792 |
|
Corresponding Author |
Naoto Kamiya, Lecturer, Department of Urology, Toho University Sakura Medical Center
564-1 Shimo-shizu, Sakura-shi, Chiba 285-8741, Japan.
E-mail: naoto.kamiya@med.toho-u.ac.jp
|
Key Words |
Prostate cancer; Docetaxel chemotherapy; Carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen; Alkaline phosphatase; Prognostic factor |
Core Tip |
This study examined the relationship between clinicopathological features and serum levels of carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen (1CTP) and alkaline phosphatase (ALP) in castration-resistant prostate cancer patients treated with docetaxel. Patients were divided into two groups according to mean + SD of serum 1CTP (8.2 ng/mL) and ALP (538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels. Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel. |
Publish Date |
2014-07-19 21:43 |
Citation |
Endo T, Kamiya N, Suzuki H, Oka R, Lee FC, Utsumi T, Yano M, Kamijima S, Kawamura K, Imamoto T, Ichikawa T. Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel. World J Clin Urol 2014; 3(2): 139-143 |
URL |
http://www.wjgnet.com/2219-2816/full/v3/i2/139.htm |
DOI |
http://dx.doi.org/10.5410/wjcu.v3.i2.139 |