Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100713
Country	Taiwan

Received	2024-08-24 06:44
Peer-Review Started	2024-08-24 06:44
To Make the First Decision
Return for Revision	2024-09-27 10:16
Revised	2024-10-09 15:33
Second Decision	2024-10-29 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 06:09
Articles in Press	2024-10-29 06:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-21 03:55
Publish the Manuscript Online	2024-12-12 09:30

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Exosomes as promising frontier approaches in future cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Fatt-Yang Chew, Chin-Hung Tsai, Kuang-Hsi Chang, Yu-Kang Chang, Ruey-Hwang Chou and Yi-Jui Liu
ORCID	Author(s) ORCID Number Fatt-Yang Chew http://orcid.org/0000-0002-8965-6131 Ruey-Hwang Chou http://orcid.org/0000-0002-2297-2180 Yi-Jui Liu http://orcid.org/0000-0001-5865-6836
Funding Agency and Grant Number	Funding Agency Grant Number China Medical University Hospital No. DMR-112-173 China Medical University Hospital No. DMR-113-089 Tungs’ Taichung Metro Harbor Hospital No. TTMHH-R1120013
Corresponding Author	Yi-Jui Liu, PhD, Professor, Department of Automatic Control Engineering, Feng Chia University, No. 100 Wenhwa Road, Seatwen, Taichung 407, Taiwan. erliu@fcu.edu.tw
Key Words	Mesenchymal stem cells; Exosomes; Gemcitabine; Pancreatic cancer; Apoptosis
Core Tip	The method of loading gemcitabine into exosomes is crucial for the effectiveness of the delivery system. The study ascertained that electroporation and sonication were more efficient than incubation in delivering gemcitabine into the human bone marrow mesenchymal stem cells-derived exosomes. Exosomes gemcitabine (Exo-GEM) demonstrated potent cytotoxicity against pancreatic cancer cells by enhancing GEM-induced apoptosis. Exo-GEM offers a promising strategy for targeted therapy in pancreatic cancer by harnessing the natural advantages of exosomes, such as high biocompatibility and the ability to navigate tumor microenvironments. Exo-GEM could deliver chemotherapy more precisely to cancer cells, reducing side effects in healthy cells.
Publish Date	2024-12-12 09:30
Citation	<p>Chew FY, Tsai CH, Chang KH, Chang YK, Chou RH, Liu YJ. Exosomes as promising frontier approaches in future cancer therapy. <i>World J Gastrointest Oncol</i> 2025; 17(1): 100713</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i1/100713.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i1.100713

Full Article (PDF)	WJGO-17-100713-with-cover.pdf
Manuscript File	100713_Auto_Edited_061556.docx
Answering Reviewers	100713-answering-reviewers.pdf
Audio Core Tip	100713-audio.mp3
Conflict-of-Interest Disclosure Form	100713-conflict-of-interest-statement.pdf
Copyright License Agreement	100713-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100713-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	100713-non-native-speakers.pdf
Peer-review Report	100713-peer-reviews.pdf
Scientific Misconduct Check	100713-scientific-misconduct-check.png
Scientific Editor Work List	100713-scientific-editor-work-list.pdf
CrossCheck Report	100713-crosscheck-report.png
CrossCheck Report	100713-crosscheck-report.pdf