Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100757
Country	China

Received	2024-08-26 02:39
Peer-Review Started	2024-09-05 01:18
To Make the First Decision
Return for Revision	2024-09-17 07:47
Revised	2024-09-26 11:19
Second Decision	2024-10-30 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-30 14:03
Articles in Press	2024-10-30 14:03
Publication Fee Transferred	2024-11-04 05:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-20 08:36
Publish the Manuscript Online	2024-12-12 09:30

ISSN	1948-5204 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Chuan Yang, Zhi-Tao Chen, Da-Long Wan, Hui Tang and Mu-Lin Liu
ORCID	Author(s) ORCID Number Yun-Chuan Yang http://orcid.org/0009-0001-7541-1192 Zhi-Tao Chen http://orcid.org/0000-0001-9469-7176 Da-Long Wan http://orcid.org/0000-0001-8912-770X Mu-Lin Liu http://orcid.org/0000-0002-4744-5715
Funding Agency and Grant Number	Funding Agency Grant Number School-Level Key Projects at Bengbu Medical College 2021byzd109
Corresponding Author	Mu-Lin Liu, PhD, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. liumulin66@aliyun.com
Key Words	Gallbladder neuroendocrine carcinoma; Targeted-gene sequencing; Bioinformatics analysis; case report; Immunocytochemistry; Case report
Core Tip	Gallbladder neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy with unclear genetic alterations and mechanisms. Our case study of a 73-year-old female with gallbladder NEC revealed 12 mutated genes (APC, ARID2, IFNA6, KEAP1, RB1, SMAD4, TP53, BTK, GATA1, GNAS, JAK2, PRDM3) and a high tumor mutation burden. Bioinformatic analysis identified significant protein-protein interactions and tumor-related functions/pathways, highlighting key regulatory factors. Gallbladder NEC exhibits distinct molecular profiles compared to other gallbladder carcinomas, emphasizing the need for tailored therapeutic strategies and further research to unravel its underlying biology.
Publish Date	2024-12-12 09:30
Citation	<p>Yang YC, Chen ZT, Wan DL, Tang H, Liu ML. Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report. <i>World J Gastrointest Oncol</i> 2025; 17(1): 100757</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i1/100757.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i1.100757

Full Article (PDF)	WJGO-17-100757-with-cover.pdf
CARE Checklist–2016	100757-CARE-Checklist-2016.pdf
Manuscript File	100757_Auto_Edited_012949.docx
Answering Reviewers	100757-answering-reviewers.pdf
Audio Core Tip	100757-audio.mp3
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Non-Native Speakers of English Editing Certificate	100757-non-native-speakers.pdf
Peer-review Report	100757-peer-reviews.pdf
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Scientific Editor Work List	100757-scientific-editor-work-list.pdf
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CrossCheck Report	100757-crosscheck-report.pdf