Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	100764
Country	South Korea

Received	2024-08-25 13:34
Peer-Review Started	2024-08-25 13:34
To Make the First Decision
Return for Revision	2024-09-10 00:55
Revised	2024-09-21 22:30
Second Decision	2024-10-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 07:23
Articles in Press	2024-10-08 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-11 05:41
Publish the Manuscript Online	2024-10-25 10:27

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Elevated ETV4 expression in cholangiocarcinoma is linked to poor prognosis and may guide targeted therapies
Manuscript Source	Invited Manuscript
All Author List	Uchenna E Okpete and Haewon Byeon
ORCID	Author(s) ORCID Number Uchenna E Okpete http://orcid.org/0000-0003-3803-4583 Haewon Byeon http://orcid.org/0000-0002-3363-390X
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program Through The National Research Foundation of Korea (NRF) Funded By The Ministry of Education NRF-RS-2023-00237287 and NRF-2021S1A5A8062526 Local Government-University Cooperation-Based Regional Innovation Projects 2021RIS-003
Corresponding Author	Haewon Byeon, DSc, PhD, Academic Editor, Associate Professor, Director, Director, Department of Digital Anti-aging Healthcare (BK21), Inje University, No. 197 Injero, Gimhae 50834, South Korea. bhwpuma@naver.com
Key Words	Prognostic biomarkers; Cholangiocarcinoma; Survival rates; ETV4 expression; PEA3 subfamily; Precision medicine; Targeted therapy
Core Tip	Cholangiocarcinoma is a highly aggressive cancer with limited treatment options. The recent study by Wang et al highlights the prognostic value of the PEA3 subfamily genes (ETV1, ETV4, and ETV5), especially ETV4, as key indicators of poor survival. Elevated ETV4 expression is linked to aggressive tumor behavior and worse outcomes. These findings offer potential for personalized treatment strategies, but further large-scale validation is required to integrate ETV4 as a prognostic biomarker and therapeutic target in clinical practice, particularly in high-incidence regions.
Publish Date	2024-10-25 10:27
Citation	<p>Okpete UE, Byeon H. Elevated ETV4 expression in cholangiocarcinoma is linked to poor prognosis and may guide targeted therapies. <i>World J Gastrointest Oncol</i> 2024; 16(11): 4528-4531</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i11/4528.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i11.4528

Full Article (PDF)	WJGO-16-4528-with-cover.pdf
Manuscript File	100764_Auto_Edited_061855.docx
Answering Reviewers	100764-answering-reviewers.pdf
Audio Core Tip	100764-audio.mp3
Conflict-of-Interest Disclosure Form	100764-conflict-of-interest-statement.pdf
Copyright License Agreement	100764-copyright-assignment.pdf
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Non-Native Speakers of English Editing Certificate	100764-non-native-speakers.pdf
Peer-review Report	100764-peer-reviews.pdf
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Scientific Editor Work List	100764-scientific-editor-work-list.pdf
CrossCheck Report	100764-crosscheck-report.pdf