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Articles Published Processes
11/27/2024 9:42:13 AM | Browse: 69 | Download: 497
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Received |
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2024-08-26 10:46 |
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Peer-Review Started |
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2024-08-26 10:46 |
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First Decision by Editorial Office Director |
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2024-09-18 04:54 |
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Return for Revision |
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2024-09-18 10:32 |
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Revised |
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2024-10-01 09:26 |
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Publication Fee Transferred |
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2024-10-29 03:31 |
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Second Decision by Editor |
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2024-10-28 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-28 05:52 |
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Articles in Press |
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2024-10-28 05:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-06 09:38 |
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Publish the Manuscript Online |
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2024-11-27 09:42 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Zinc pretreatment for protection against intestinal ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Zhen Cheng, Jia-Hao Luo, Xin Li, Feng-Yong Liu and Wei-Jie Zhou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Jie Zhou, PhD, Professor, State Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. weijiezhouum@163.com |
| Key Words |
Intestinal ischemia-reperfusion injury; Zinc pretreatment; Reactive oxygen species; Oxidative stress; Intestinal organoids; Caco-2 cells |
| Core Tip |
This study demonstrated the protective effects of zinc pretreatment on reducing oxidative stress, apoptosis, and multiorgan damage during intestinal ischemia-reperfusion injury (II/RI). Using mouse models and in vitro systems, zinc significantly mitigated damage in the intestine, liver, and kidneys by reducing reactive oxygen species production and enhancing cellular resilience to hypoxic injury. These findings highlight the potential clinical applications of zinc in protecting against II/RI and improving outcomes in patients experiencing ischemic events. |
| Publish Date |
2024-11-27 09:42 |
| Citation |
Cheng MZ, Luo JH, Li X, Liu FY, Zhou WJ. Zinc pretreatment for protection against intestinal ischemia-reperfusion injury. World J Gastrointest Surg 2024; 16(12): 3843-3856 |
| URL |
https://www.wjgnet.com/1948-9366/full/v16/i12/3843.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i12.3843 |
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