| ISSN |
1948-5190 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn’s disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Masashi Ohno, Atsushi Nishida, Akinori Otsuki, Yoshihiro Yokota, Takayuki Imai, Shigeki Bamba and Osamu Inatomi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan |
No. 21K15947 |
| Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan |
No. 23K07435 |
|
| Corresponding Author |
Masashi Ohno, Assistant Professor, MD, PhD, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Shiga, Japan. ohno116@belle.shiga-med.ac.jp |
| Key Words |
Crohn’s disease; Leucine-rich alpha-2 glycoprotein; Endoscopic activity; Ileum; Small intestine; Balloon-assisted enteroscopy |
| Core Tip |
Targeting endoscopic healing (EH) is crucial, particularly in small bowel Crohn’s disease (CD), as EH is associated with better long-term outcomes. We have evaluated the usefulness of leucine-rich alpha-2 glycoprotein (LRG) as a biomarker in assessing EH and endoscopic activity in 133 consecutive patients with CD who underwent balloon-assisted enteroscopy. Our results indicate the usefulness of LRG in assessing EH and endoscopic activity in CD. Furthermore, the superiority of LRG over C-reactive protein has been demonstrated, especially in predicting EH in the small intestine. |
| Publish Date |
2025-02-13 02:41 |
| Citation |
<p>Ohno M, Nishida A, Otsuki A, Yokota Y, Imai T, Bamba S, Inatomi O. Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn’s disease. <i>World J Gastrointest Endosc</i> 2025; 17(2): 100793</p> |
| URL |
https://www.wjgnet.com/1948-5190/full/v17/i2/100793.htm |
| DOI |
https://dx.doi.org/10.4253/wjge.v17.i2.100793 |
