Publication Name	World Journal of Gastroenterology
Manuscript ID	100802
Country	China

Received	2024-08-27 08:38
Peer-Review Started	2024-08-28 08:48
To Make the First Decision
Return for Revision	2024-09-15 20:21
Revised	2024-09-23 16:43
Second Decision	2024-10-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 05:57
Articles in Press	2024-10-08 05:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-14 15:14
Publish the Manuscript Online	2024-10-23 04:32

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice
Manuscript Source	Invited Manuscript
All Author List	Jin Wang, Yao Meng and Zhi-Guo Guo
ORCID	Author(s) ORCID Number Yao Meng http://orcid.org/0000-0002-1634-134X Zhi-Guo Guo http://orcid.org/0000-0002-6053-1263
Funding Agency and Grant Number
Corresponding Author	Zhi-Guo Guo, MD, Chief Physician, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, No. 616 Bianyangsan Road, Suzhou 234000, Anhui Province, China. zhigg0268@sina.com
Key Words	Fecal microbiota transplantation; Mesenteric adipose tissue; Creeping fat; Inflammation; Intestinal fibrosis; Crohn's disease
Core Tip	Mesenteric adipose tissue and creeping fat (CrF) may play a potential role in Crohn's disease (CD) progression, providing new insights and promising avenues for therapeutic intervention. Fecal microbiota transplantation (FMT) from healthy donors may partially mitigate intestinal inflammatory infiltration, improve intestinal permeability, enhance barrier function, and reduce systemic inflammation in patients with CD. Conversely, FMT from CD patients exacerbates inflammatory changes and contributes to intestinal wall fibrosis. In the present study, we found that the gut microbiota plays a multifaceted role, mediating the properties of CrF and influencing the inflammatory and fibrotic phenotypes associated with CD.
Publish Date	2024-10-23 04:32
Citation	<p>Wang J, Meng Y, Guo ZG. Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice. <i>World J Gastroenterol</i> 2024; 30(41): 4514-4517</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i41/4514.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i41.4514

Full Article (PDF)	WJG-30-4514-with-cover.pdf
Manuscript File	100802_Auto_Edited_061600.docx
Answering Reviewers	100802-answering-reviewers.pdf
Audio Core Tip	100802-audio.mp3
Conflict-of-Interest Disclosure Form	100802-conflict-of-interest-statement.pdf
Copyright License Agreement	100802-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100802-non-native-speakers.pdf
Peer-review Report	100802-peer-reviews.pdf
Scientific Misconduct Check	100802-scientific-misconduct-check.png
Scientific Editor Work List	100802-scientific-editor-work-list.pdf
CrossCheck Report	100802-crosscheck-report.pdf