Publication Name	World Journal of Clinical Cases
Manuscript ID	100833
Country	China

Received	2024-08-27 15:12
Peer-Review Started	2024-08-27 15:12
To Make the First Decision
Return for Revision	2024-09-14 03:52
Revised	2024-09-26 11:11
Second Decision	2024-10-16 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-16 10:50
Articles in Press	2024-10-16 10:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-18 16:44
Typeset the Manuscript	2024-10-28 15:16
Publish the Manuscript Online	2024-11-07 05:11

ISSN	2307-8960 (online)
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Category	Neurosciences
Manuscript Type	Editorial
Article Title	Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways
Manuscript Source	Invited Manuscript
All Author List	Hua Bai and Xiao-Feng Feng
ORCID	Author(s) ORCID Number Hua Bai http://orcid.org/0000-0002-5617-0215
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) No. 32060182 Qiannan Prefecture Science and Technology Plan Project in China No. Qiannan Kehe She Zi [2022] No. 1
Corresponding Author	Hua Bai, MD, PhD, Department of Neurology, The Third Affiliated Hospital of Guizhou Medical University in China, No. 172 JianJiangbei Road, Duyun 558099, Guizhou Province, China. baih2020@gmc.edu.cn
Key Words	Alzheimer's disease; Dementia; Cholinesterase inhibitor; Beta amyloid; Tau protein
Core Tip	The therapeutic targets for acetylcholinesterase (AChE), N-methyl-D-aspartate glutamate receptor, amyloid (Aβ) protein, tau protein and immune inflammation are still the main direction of developing Alzheimer's disease (AD) drugs. Several classical AChE inhibitors are worth keeping; Although there are many experimental research results on antibodies against Aβ or tau protein, there are few successful clinical trials of drugs. The development of new drugs for chronic immune inflammation to treat AD is still in the animal experimental stage. It is necessary to establish a multi-target-oriented precision treatment system for many key links and aspects involved in the pathogenesis of AD.
Publish Date	2024-11-07 05:11
Citation	<p>Bai H, Feng XF. Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways. <i>World J Clin Cases</i> 2025; 13(1): 100833</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i1/100833.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i1.100833

Full Article (PDF)	WJCC-13-100833-with-cover.pdf
Manuscript File	100833_Auto_Edited_085325.docx
Answering Reviewers	100833-answering-reviewers.pdf
Audio Core Tip	100833-audio.wav
Conflict-of-Interest Disclosure Form	100833-conflict-of-interest-statement.pdf
Copyright License Agreement	100833-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100833-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	100833-non-native-speakers.pdf
Peer-review Report	100833-peer-reviews.pdf
Scientific Misconduct Check	100833-scientific-misconduct-check.png
Scientific Editor Work List	100833-scientific-editor-work-list.pdf
CrossCheck Report	100833-crosscheck-report.pdf