| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Zhi Hao, Hai-Lan Lin, Yu-Bin Hu, Qi-Zhong Chen, Zhang-Xian Chen, Lin-Bin Qiu, Duan-Yu Lin, Hui Zhang, De-Chun Zheng, Zhu-Ting Fang and Jing-Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Fujian Key Laboratory of Translational Cancer Medicine and The Yttrium Little Red Flower Health Fund Project of Henan Sunshine Medical and Health Development Foundation |
No. HKP2024001 |
|
| Corresponding Author |
Jing-Feng Liu, PhD, Department of Hepatobiliary Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350014, Fujian Province, China. drjingfeng@126.com |
| Key Words |
Selective internal radiation therapy; Hepatic arterial infusion chemotherapy; Yttrium-90 resin microspheres; Hepatocellular carcinoma; Conversion therapy; Case report |
| Core Tip |
Although selective internal radiation therapy (SIRT) has been used to treat unresectable hepatic cancers for more than 20 years, it is mainly employed to treat patients with ≤ 8 cm tumor size. This research reports a hepatocellular carcinoma patient with > 15 cm hepatic mass, microvascular invasion, and China Liver Cancer Staging (CNLC) IIIa who received radical hepatectomy after successful conversion therapy with SIRT using yttrium-90 resin microspheres followed by hepatic arterial infusion chemotherapy using anti-programmed death-1 antibody and tyrosine kinase inhibitor. After 4 months of SIRT, the tumor was downstaged to CNLC Ib and the future liver remnant increased from 434 mL to 802 mL. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
<p>Hao MZ, Lin HL, Hu YB, Chen QZ, Chen ZX, Qiu LB, Lin DY, Zhang H, Zheng DC, Fang ZT, Liu JF. Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma: A case report. <i>World J Gastrointest Oncol</i> 2025; 17(3): 100861</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/100861.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.100861 |
