| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Yu Chen, Pei-Yao Wang, Bang Liu, Yang-Pu Jia, Zhao-Xiong Zhang, Xin Liu, Dao-Han Wang, Yong-Jia Yan, Wei-Hua Fu and Feng Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundamental Research Program of Shanxi Province |
202203021222418 |
| Research Program of Shanxi Provincial Health Commission |
2023061 |
| Fundamental Research Cooperation Program of Beijing-Tianjin-Hebei Region of Natural Science Foundation of Tianjin |
22JCZXJC00140 |
| Tianjin Major Science and Technology Project |
21ZXJBSY00110 |
| Tianjin Health and Science and Technology Project |
TJWJ2024ZK001 |
|
| Corresponding Author |
Wei-Hua Fu, MD, PhD, Professor, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, No. 154 Anshan Road, Tianjin 300052, China. tjmughgs_fwh@163.com |
| Key Words |
Gastric cancer; Prognosis; Regulator of G protein signaling 4; Focal adhesion kinase; Epithelial-mesenchymal transition |
| Core Tip |
This study explored the relevant role of regulator of G protein signaling 4 (RGS4) in gastric cancer (GC) and its possible mechanism. Through analysis of public databases, validation of clinical specimens, cell experiments and xenograft model, our study confirmed that RGS4 promotes GC progression through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition. RGS4 is a potential therapeutic target for GC and our study may further guide clinical practice. |
| Publish Date |
2024-12-18 07:36 |
| Citation |
<p>Chen PY, Wang PY, Liu B, Jia YP, Zhang ZX, Liu X, Wang DH, Yan YJ, Fu WH, Zhu F. RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition. <i>World J Gastroenterol</i> 2025; 31(2): 100898</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i2/100898.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i2.100898 |
