| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Informatics |
| Manuscript Type |
Retrospective Study |
| Article Title |
Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Liang, Xiao-Sheng Li, Ze-Jun Huang, Zu-Hai Hu, Qian-Jie Xu, Yu-Liang Yuan, Wei Zhang and Hai-Ke Lei |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Hai-Ke Lei, Associate Professor, Chongqing Cancer Multi-omics Big Data Application Engineering Research Center, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400030, China. tohaike@163.com |
| Key Words |
Rectal cancer; Overall survival; Nomogram; Prognosis |
| Core Tip |
This study developed and validated a novel prognostic nomogram for rectal cancer, incorporating demographic, clinicopathological, haematological, and follow-up data. The prognostic factors include Karnofsky performance status, age, sex, TNM stage, chemotherapy, surgery, targeted therapy, β2-microglobulin, lactate dehydrogenase (LDH), and neutrophil-to-lymphocyte ratio. Compared to the TNM staging system, the nomogram demonstrated high accuracy in predicting 1-year, 3-year, and 5-year overall survival (C-index 0.80), with excellent generalizability and clinical utility. It provides a reliable tool for personalized interventions. However, further research is needed to explore the role of β2-microglobulin and LDH in the progression of rectal cancer and to validate the model. |
| Publish Date |
2025-01-18 08:11 |
| Citation |
<p>Liang L, Li XS, Huang ZJ, Hu ZH, Xu QJ, Yuan YL, Zhang W, Lei HK. Development and validation of a nomogram prediction model for overall survival in patients with rectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(2): 100908</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i2/100908.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i2.100908 |
