| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Man Liu, Ying-Lan Ji, Yu-Jie Hu, Ying-Xi Su, Jie Yang, Xiao-Yi Wang, Hong-Yu Chu, Xue Zhang, Shi-Jing Dong, Hui Yang, Yu-Hang Liu, Si-Min Zhou, Li-Ping Guo, Ying Ran, Yan-Ni Li, Jing-Wen Zhao, Zhi-Guang Zhang, Mei-Yu Piao and Lu Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Health Research Project |
TJWJ2024QN005 |
| Beijing iGandan Public Welfare Foundation Artificial Liver Special Fund |
iGandanF-1082024-RGG122 |
|
| Corresponding Author |
Lu Zhou, MD, Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, No. 154 Anshan Road, Tianjin 300070, China. zhou_lu@126.com |
| Key Words |
Cholestasis; Microbiota; Lactococcus garvieae; Intestinal permeability; Bile acid |
| Core Tip |
Mice gavaged with Lactococcus garvieae (L. garvieae) exhibited marked aggravation of cholestasis, portal edema, portal infiltrates, liver fibrosis during CLD compared with control mice. Mechanically, L. garvieae treatment decreased the expression of intestinal tight junction proteins and enhanced BA reabsorption in CLD mice. |
| Publish Date |
2025-02-26 04:21 |
| Citation |
<p>Liu M, Ji YL, Hu YJ, Su YX, Yang J, Wang XY, Chu HY, Zhang X, Dong SJ, Yang H, Liu YH, Zhou SM, Guo LP, Ran Y, Li YN, Zhao JW, Zhang ZG, Piao MY, Zhou L. Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption. <i>World J Gastroenterol</i> 2025; 31(10): 101014</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i10/101014.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i10.101014 |
