Publication Name	World Journal of Gastroenterology
Manuscript ID	10107
Country	China

Received	2014-03-14 08:47
Peer-Review Started	2014-03-14 13:51
To Make the First Decision	2014-04-02 19:31
Return for Revision	2014-04-15 04:24
Revised	2014-04-25 09:54
Second Decision	2014-07-22 16:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 18:22
Articles in Press	2014-07-22 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-30 17:25
Typeset the Manuscript	2014-08-01 14:03
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao Yang, Tao-Fang Xi, Yu-Xian Li, Hai-Hong Wang, Ying Qin, Jie-Ping Zhang, Wen-Ting Cai, Meng-Ting Huang, Ji-Qiao Shen, Xi-Min Fan, Xuan-Zheng Shi and Dong-Ping Xie
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30872475 National Natural Science Foundation of China 31271234
Corresponding Author	Dong-Ping Xie, MD, PhD, Department of Physiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. xiedping@tongji.edu.cn
Key Words	Intragastric cold water stress; Colonic motility; Estradiol; Oxytocin; Oxytocin receptor; Irritable bowel syndrome
Core Tip	Colon transit was decreased and oxytocin-induced inhibition of colonic contraction was enhanced in rats with cold water intake. Atosiban and tetrodotoxin inhibited the effect of oxytocin on colonic motility. Cold water intake increased blood concentration of oxytocin and expression of oxytocin receptors in colon. Estradiol regulated blood concentration of oxytocin and oxytocin-induced colonic contraction. The results suggested that cold water intake inhibited colonic motility through oxytocin-oxytocin receptor signaling in the myenteric nervous system pathway, which is estrogen dependent. The estradiol-oxytocin-oxytocin receptor-colonic contractile pathway might be a new therapeutic target for irritable bowel syndrome in females.
Publish Date	2014-08-20 18:38
Citation	Yang X, Xi TF, Li YX, Wang HH, Qin Y, Zhang JP, Cai WT, Huang MT, Shen JQ, Fan XM, Shi XZ, Xie DP. Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors. World J Gastroenterol 2014; 20(31): 10886-10894
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10886.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10886

Full Article (PDF)	WJG-20-10886.pdf
Full Article (Word)	WJG-20-10886.doc
Manuscript File	10107-Review.doc
Answering Reviewers	10107-Answering reviewers.pdf
Copyright License Agreement	10107-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10107-Language certificate.PDF
Peer-review Report	10107-Peer review.pdf
Scientific Misconduct Check	10107-CrossCheck.JPG
Scientific Editor Work List	10107-Scientific editor work list.pdf