BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/20/2014 6:38:00 PM | Browse: 492 | Download: 546
Publication Name World Journal of Gastroenterology
Manuscript ID 10107
Country/Territory China
Received
2014-03-14 08:47
Peer-Review Started
2014-03-14 13:51
To Make the First Decision
2014-04-02 19:31
Return for Revision
2014-04-15 04:24
Revised
2014-04-25 09:54
Second Decision
2014-07-22 16:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-22 18:22
Articles in Press
2014-07-22 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-30 17:25
Typeset the Manuscript
2014-08-01 14:03
Publish the Manuscript Online
2014-08-20 18:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors
Manuscript Source Unsolicited Manuscript
All Author List Xiao Yang, Tao-Fang Xi, Yu-Xian Li, Hai-Hong Wang, Ying Qin, Jie-Ping Zhang, Wen-Ting Cai, Meng-Ting Huang, Ji-Qiao Shen, Xi-Min Fan, Xuan-Zheng Shi and Dong-Ping Xie
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30872475
National Natural Science Foundation of China 31271234
Corresponding author Dong-Ping Xie, MD, PhD, Department of Physiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. xiedping@tongji.edu.cn
Keywords Intragastric cold water stress; Colonic motility; Estradiol; Oxytocin; Oxytocin receptor; Irritable bowel syndrome
Core Tip Colon transit was decreased and oxytocin-induced inhibition of colonic contraction was enhanced in rats with cold water intake. Atosiban and tetrodotoxin inhibited the effect of oxytocin on colonic motility. Cold water intake increased blood concentration of oxytocin and expression of oxytocin receptors in colon. Estradiol regulated blood concentration of oxytocin and oxytocin-induced colonic contraction. The results suggested that cold water intake inhibited colonic motility through oxytocin-oxytocin receptor signaling in the myenteric nervous system pathway, which is estrogen dependent. The estradiol-oxytocin-oxytocin receptor-colonic contractile pathway might be a new therapeutic target for irritable bowel syndrome in females.
Publish Date 2014-08-20 18:38
Citation Yang X, Xi TF, Li YX, Wang HH, Qin Y, Zhang JP, Cai WT, Huang MT, Shen JQ, Fan XM, Shi XZ, Xie DP. Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors. World J Gastroenterol 2014; 20(31): 10886-10894
Url http://www.wjgnet.com/1007-9327/full/v20/i31/10886.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i31.10886
Full Article (PDF) WJG-20-10886.pdf
Full Article (Word) WJG-20-10886.doc
Manuscript File 10107-Review.doc
Answering Reviewers 10107-Answering reviewers.pdf
Copyright License Agreement 10107-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10107-Language certificate.PDF
Peer-review Report 10107-Peer review.pdf
Scientific Misconduct Check 10107-CrossCheck.JPG
Scientific Editor Work List 10107-Scientific editor work list.pdf