| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in CKD: A systematic review and meta-analysis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdul Hannan Siddiqui, Fizzah Batool, Shayan Khan, Syed Shabbeer Rizvi, Saad Usman, Huzaifa Jawed, Muhammad Hammad Ali, Tatheer Zehra, Abdul Rafay Adil, Masifah Anwar, Areeba Hanif, Saad Khalid Hassan, Mark William Noble, Abdul Moeed and Salim Surani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdul Hannan Siddiqui, Department of Internal Medicine, Dow University of Health Sciences, Mission Rd, Karachi 74200, Sindh, Pakistan. abdul.siddiqui19@dmc.duhs.edu.pk |
| Key Words |
Chronic kidney disease; Metabolic acidosis; Safety and efficacy; Sodium bicarbonate |
| Core Tip |
Sodium bicarbonate is a systemic alkalizer that increases serum bicarbonate, buffers hydrogen ions, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is often prescribed for the treatment of metabolic acidosis seen in severe renal disease. Studies have been conducted to assess the safety and efficacy of sodium bicarbonate as a pH equalizer. This meta-analysis aims to compare sodium bicarbonate with a placebo to evaluate the safety profile and clinical efficacy in treating metabolic acidosis in patients with chronic kidney disease (CKD). |
| Publish Date |
2025-01-20 08:27 |
| Citation |
<p>Siddiqui AH, Batool F, Khan S, Rizvi SS, Usman S, Jawed H, Ali MH, Zehra T, Adil AR, Anwar M, Hanif A, Hassan SK, Noble MW, Moeed A, Surani S. Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in CKD: A systematic review and meta-analysis. <i>World J Nephrol</i> 2025; 14(1): 101078</p> |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i1/101078.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i1.101078 |
