Publication Name	World Journal of Orthopedics
Manuscript ID	10111
Country	Italy

Received	2014-03-14 09:09
Peer-Review Started	2014-03-14 10:27
To Make the First Decision	2014-05-14 13:48
Return for Revision	2014-05-15 19:32
Revised	2014-06-04 05:08
Second Decision	2014-08-31 16:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-08-31 17:03
Articles in Press	2014-08-31 17:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-13 20:47
Publish the Manuscript Online	2015-01-20 11:19

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes
Manuscript Source	Invited Manuscript
All Author List	Antonino Tuttolomondo, Carlo Maida and Antonio Pinto
Funding Agency and Grant Number
Corresponding Author	Antonino Tuttolomondo, MD, PhD, Professor, Dipartimento Biomedico di Medicina Interna e Specialistica, U.O.C di Medicina Interna e Cardioangiologia, Università degli Studi di Palermo, P.zza delle Cliniche n.2, 90127 Palermo, Italy. bruno.tuttolomondo@unipa.it
Key Words	Diabetic foot syndrome; Inflammation; Cytokines; Cardiovascular risk; Marker
Core Tip	An immune activation has been reported as important at several stages in the development of chronic wounds of diabetic foot syndrome (DFS). Immune-inflammatory up regulation may precede the incidence of DFS in the same way that it precedes some major cardiovascular diabetic complication such as coronary heart disease as reported by some studies that showed a significant negative correlation of adiponectin plasma levels with cardiovascular risk factors such as hypertension, dyslipidaemia and with previous cerebrovascular events such as previous transient ischemic attack/stroke and new onset events thus underlining the role of hypo-adiponectinaemia as a cardiovascular predictive factor in DFS.
Publish Date	2015-01-20 11:19
Citation	Tuttolomondo A, Maida C, Pinto A. Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes. World J Orthop 2015; 6(1): 62-76
URL	http://www.wjgnet.com/2218-5836/full/v6/i1/62.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i1.62

Full Article (PDF)	WJO-6-62.pdf
Full Article (Word)	WJO-6-62.doc
Manuscript File	10111-Review.doc
Answering Reviewers	10111-Answering reviewers.pdf
Copyright License Agreement	10111-Copyright assignment.pdf
Peer-review Report	10111-Peer review(s).pdf
Scientific Misconduct Check	10111-CrossCheck.jpg
Scientific Editor Work List	10111-Scientific editor work list.pdf