Publication Name	World Journal of Gastroenterology
Manuscript ID	101158
Country	China

Received	2024-09-05 13:14
Peer-Review Started	2024-09-05 13:14
To Make the First Decision
Return for Revision	2024-09-15 19:51
Revised	2024-09-20 04:59
Second Decision	2024-09-26 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-26 05:50
Articles in Press	2024-09-26 05:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-21 22:10
Typeset the Manuscript	2024-10-25 04:11
Publish the Manuscript Online	2024-10-31 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Sepsis-associated liver injury: Mechanisms and potential therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Jia-Wen Chen, Chen-Yi Liu, Shu Li, Shi-Wen Wu, Chao Cai and Ming-Qin Lu
ORCID	Author(s) ORCID Number Chao Cai http://orcid.org/0000-0001-5920-4938 Ming-Qin Lu http://orcid.org/0000-0002-8331-5862
Funding Agency and Grant Number	Funding Agency Grant Number The Zhejiang Medical and Health Science and Technology Program, China No. 2021KY205 The Zhejiang Medical and Health Science and Technology Program, China No. 2024KY139 The Wenzhou Science and Technology Plan Project, China No. Y2023111
Corresponding Author	Ming-Qin Lu, Doctor, MD, Chief Physician, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, No. 1 Fanhai West Road, Ouhai District, Wenzhou 325000, Zhejiang Province, China. lmq0906@163.com
Key Words	Sepsis; Sepsis-associated liver injury; Gut-liver axis; Immunosuppression; Inflammation; Immune dysregulation; Glucocorticoid; Adrenal cortical insufficiency
Core Tip	Immunosuppression is a key aspect of progressive sepsis. Assessing this state is crucial for managing sepsis-associated liver injury and guiding therapeutic choices. Suppression of D-related human leucocyte antigen (HLA-DR) expression, along with changes in clinical presentation and tests, may indicate an immunosuppressive phase. Hormonal interventions based on HLA-DR levels could potentially alter outcomes in severe infections. However, large-scale studies on glucocorticoid therapy for sepsis show inconsistent results, likely due to inadequate assessment of the host's immune status.
Publish Date	2024-10-31 10:39
Citation	<p>Chen JW, Liu CY, Li S, Wu SW, Cai C, Lu MQ. Sepsis-associated liver injury: Mechanisms and potential therapeutic targets. <i>World J Gastroenterol</i> 2024; 30(42): 4518-4522</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i42/4518.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i42.4518

Full Article (PDF)	WJG-30-4518-with-cover.pdf
Manuscript File	101158_Auto_Edited_012720.docx
Answering Reviewers	101158-answering-reviewers.pdf
Audio Core Tip	101158-audio.mp3
Conflict-of-Interest Disclosure Form	101158-conflict-of-interest-statement.pdf
Copyright License Agreement	101158-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101158-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101158-non-native-speakers.pdf
Peer-review Report	101158-peer-reviews.pdf
Scientific Misconduct Check	101158-scientific-misconduct-check.png
Scientific Editor Work List	101158-scientific-editor-work-list.pdf
CrossCheck Report	101158-crosscheck-report.pdf